{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:07:40Z","timestamp":1773392860357,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,8,19]],"date-time":"2018-08-19T00:00:00Z","timestamp":1534636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Optimal imaging for children with pediatric malignant melanoma (MM) is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed clinical and imaging findings of patients with American Joint Commission on Cancer (AJCC) stage IIC\u2010IV MM treated on our institutional MEL06 trial. All patients had baseline brain magnetic resonance imaging\/computed tomography (MRI\/CT), positron emission tomography\/computed tomography (PET\/CT), CT chest, abdomen, and pelvis (CTCAP). Patients on stratum A (PEG\u2010interferon, where PEG is pegylated; AJCC IIC, IIIA, IIIB; <jats:italic>n<\/jats:italic>\u00a0=\u00a016) had imaging every 6\u00a0months; stratum B1 (PEG\u2010interferon and temozolomide; unresectable measurable disease, metastatic, or recurrent; <jats:italic>n<\/jats:italic>\u00a0=\u00a02) had PET\/CT scans every 2\u00a0months and brain imaging studies every 4\u00a0months; stratum B2 patients (PEG\u2010interferon and temozolomide; unresectable nonmeasurable, metastatic, or recurrent, <jats:italic>n<\/jats:italic>\u00a0=\u00a03) had imaging every 4\u00a0months. Off\u2010therapy imaging was done every 6 months for 3 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 21 patients (11 females, 11 spitzoid, median age 14\u00a0years, head\/neck [6], trunk [7], extremities [8]). Patients with spitzoid melanoma underwent 236 imaging studies in total (86 PET\/CT, 81 CTCAP, 11 CT chest, 10 CT brain, 48 MRI brain) at a median cost per patient of $32,718. Thirteen studies (5.8%) had findings that led to two biopsies (one positive). For conventional MM, 162 studies (61 PET\/CT, 57 CTCAP, 8 CT chest, 7 CT brain, and 29 MRI brain) were performed with a median cost per patient of $23,420. Twenty (14%) had findings leading to six biopsies (four positive). At 6.3\u00a0years (range 0.4\u20109.2), 17 patients remain disease\u2010free.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children with spitzoid melanoma require minimal imaging at diagnosis and follow\u2010up. Patients with conventional MM should be imaged according to adult guidelines.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27412","type":"journal-article","created":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T03:46:40Z","timestamp":1534736800000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The role of routine imaging in pediatric cutaneous melanoma"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4803-1976","authenticated-orcid":false,"given":"Hadeel","family":"Halalsheh","sequence":"first","affiliation":[{"name":"Department of Oncology St Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue C.","family":"Kaste","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging St Jude Children's Research Hospital  Memphis Tennessee"},{"name":"Department of Radiology University of Tennessee School of Health Science  Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fariba","family":"Navid","sequence":"additional","affiliation":[{"name":"Division of Hematology Oncology and Bone Marrow Transplant Children's Hospital Los Angeles  California"},{"name":"Keck School of Medicine University of Southern California  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8515-2649","authenticated-orcid":false,"given":"Armita","family":"Bahrami","sequence":"additional","affiliation":[{"name":"Department of Pathology St Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4784-7914","authenticated-orcid":false,"given":"Barry L.","family":"Shulkin","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging St Jude Children's Research Hospital  Memphis Tennessee"},{"name":"Department of Radiology University of Tennessee School of Health Science  Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhaskar","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Surgery St Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Kunkel","sequence":"additional","affiliation":[{"name":"Cancer Center Administration St Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Artz","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging St Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Pappo","sequence":"additional","affiliation":[{"name":"Department of Oncology St Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.02.050"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.425"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25983"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep11200"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.14.13892"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9347-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12602"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e32833716f9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.091"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01396205"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.4.638"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9399-3"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.15_suppl.9517"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.15_suppl.9586"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq455"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2014.01.002"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0007-0963.2004.05870.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-0238-y"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70283-7"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990201)85:3<750::AID-CNCR26>3.0.CO;2-5"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.2063"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04686.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22584"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2011.03.008"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318217e852"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.4799"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.22.3782"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-018-0676-z"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30142-6"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23746"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0901249"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f2360"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60815-0"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-008-1026-3"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12112678"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/25922439"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-013-1187-0"},{"issue":"1","key":"e_1_2_8_39_1","first-page":"I","article-title":"The relationship between procedural sedation during treatment and neurocognitive outcomes in survivors of pediatric medulloblastoma","volume":"23","author":"Jacola LA","year":"2017","journal-title":"J Int Neuropsy Soc"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2004.12.008"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970915)80:6<1052::AID-CNCR7>3.0.CO;2-B"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.27412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.27412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T16:09:08Z","timestamp":1694794148000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.27412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,19]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1002\/pbc.27412"],"URL":"https:\/\/doi.org\/10.1002\/pbc.27412","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,19]]},"assertion":[{"value":"2018-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e27412"}}