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Initiatives have focused on increasing accrual, but changes at the population\u2010level are unknown. We examined patterns of clinical trial participation over time in AYA patients with cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We utilized medical record data from AYAs in two population\u2010based National Cancer Institute Patterns of Care Studies identified through the Surveillance, Epidemiology and End Results Program. Among 3135 AYAs diagnosed with non\u2010Hodgkin lymphoma (NHL), Hodgkin lymphoma, acute lymphoblastic leukemia (ALL), and sarcoma, we used multivariate logistic regression to evaluate patient and provider characteristics associated with clinical trial enrollment. Interaction terms evaluated variation in clinical trial enrollment across patient and provider characteristics by year of diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2006 to 2012\u20132013, clinical trial participation increased from 14.8% to 17.9% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Adjusting for patient and provider characteristics, we found lower clinical trial enrollment among those who were older at diagnosis, diagnosed with NHL vs ALL, treated by adult hematologist\/oncologists only (vs pediatric hematologist\/oncologists), and of non\u2010Hispanic Black race\/ethnicity (vs non\u2010Hispanic White) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05 for all). Interaction analyses indicate improved clinical trial enrollment from 2006 to 2012\u20132013 among young adults 25\u201329 years of age and the uninsured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although disparities in enrollment onto clinical trials remain for AYAs with cancer, our study identified increasing overall clinical trial participation over time.\u00a0Further, we identify promising trends in enrollment uptake among AYAs 25\u201329 years of age and the uninsured.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27426","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T11:01:10Z","timestamp":1536231670000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Increased clinical trial enrollment among adolescent and young adult cancer patients between 2006 and 2012\u20132013 in the United States"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3822-9858","authenticated-orcid":false,"given":"Helen M.","family":"Parsons","sequence":"first","affiliation":[{"name":"Division of Health Policy and Management University of Minnesota  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolly C.","family":"Penn","sequence":"additional","affiliation":[{"name":"National Cancer Institute  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Oncology Hematology Outcomes Research and Training (COHORT) and Division of Hematology and Oncology University of California Davis School of Medicine  Sacramento California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary D.","family":"Cress","sequence":"additional","affiliation":[{"name":"Public Health Institute Cancer Registry of Greater California  Sacramento California"},{"name":"Department of Public Health Sciences University of California Davis School of Medicine  Davis California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad H.","family":"Pollock","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of California Davis School of Medicine  Davis California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio H.","family":"Malogolowkin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California Davis School of Medicine  Sacramento California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted","family":"Wun","sequence":"additional","affiliation":[{"name":"Center for Oncology Hematology Outcomes Research and Training (COHORT) and Division of Hematology and Oncology University of California Davis School of Medicine  Sacramento California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa H.M.","family":"Keegan","sequence":"additional","affiliation":[{"name":"Center for Oncology Hematology Outcomes Research and Training (COHORT) and Division of Hematology and Oncology University of California Davis School of Medicine  Sacramento California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29869"},{"key":"e_1_2_8_3_1","volume-title":"Cancer Epidemiology in Older Adolescents and Young Adults 15 to 29 Years of Age, including SEER Incidence and Survival: 1975\u20132000","author":"Bleyer WA","year":"2006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29870"},{"key":"e_1_2_8_5_1","unstructured":"Adolescent and Young Adult Oncology Progress Review Group.Closing the gap: research and care imperatives for adolescent and young adults with cancer.2006;https:\/\/www.cancer.gov\/types\/aya\/research\/ayao-august-2006.pdf. 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