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Some studies in adults demonstrated that equivalent doses of GI and branded imatinib (BI) result in comparable plasma concentrations and clinical efficacy. However, other studies found that GI users are more likely to stop imatinib, with intolerance and decreased persistence as the main causes. Economic factors also heavily influence GI selection. This article aims to review the present knowledge to support further discussion on the role of GI in the management of pediatric Ph+ leukemia.<\/jats:p>","DOI":"10.1002\/pbc.27431","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T13:12:18Z","timestamp":1535634738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Generic formulations of imatinib for treatment of Philadelphia chromosome\u2013positive leukemia in pediatric patients"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9522-8838","authenticated-orcid":false,"given":"Meinolf","family":"Suttorp","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology and Oncology University Hospital Carl Gustav Carus Technical University  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Metzler","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology University Hospital University of Erlangen  Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Millot","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Unit University Hospital  Poitiers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1009-7649","authenticated-orcid":false,"given":"Deepak","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology Postgraduate Institute of Medical Education &amp; Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adalet Meral","family":"G\u00fcnes","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Uluda\u011f University Hospital  G\u00f6r\u00fckle Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Kalwak","sequence":"additional","affiliation":[{"name":"Department of Pediatric Bone Marrow Transplantation Oncology and Hematology Medical University  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Sedlacek","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Teaching Hospital Motol 2nd Medical School Charles University Motol  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Baruchel","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\u2010Immunology Department University Hospital Robert Debr\u00e9 (APHP)  Paris France"},{"name":"Pediatric Hematology\u2010Immunology Department Paris Diderot University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Biondi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tettamanti Research Center University of Milano\u2010Bicocca  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0199-054X","authenticated-orcid":false,"given":"Nobuko","family":"Hijiya","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology and Stem Cell Transplant Ann and Robert H. 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