{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T16:14:09Z","timestamp":1764260049730,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T00:00:00Z","timestamp":1538265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Enteroviruses (EV) are a large group of Picornaviruses associated with respiratory, gastrointestinal, and neurologic symptoms in the immunocompetent host. Little is known about the epidemiologic and clinical impact in pediatric hematologic\/oncologic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>From 2001 through 2017, different clinical specimens were collected from pediatric hematologic\/oncologic patients and were tested for enteroviral RNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 13\u00a0004 specimens collected from 761 patients, 38 (0.3%) obtained from 14 patients (1.8%) tested positive for EV RNA. Viral shedding was observed without viremia and vice versa. None of 80 cerebrospinal fluid specimens obtained from 60 patients with neurologic symptoms were positive for EV RNA. None of 14 patients positive for EV RNA showed EV\u2010specific symptoms. In 11\/14 patients, EV RNA was found to be negative in the follow\u2010up specimen. The remaining patient with a severe primary immune deficiency showed repeated positive EV RNA results for &gt;5 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this pediatric hematologic\/oncologic cohort, EV infection occurred rarely and without related symptoms. Specimens concurrently obtained from one patient are commonly not in accordance with each other. In the vast majority of patients, EV RNA appears to turn negative in the follow\u2010up specimen. EV infections seem to have a low impact in this patient cohort.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27448","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T05:24:28Z","timestamp":1538371468000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Enterovirus infections in pediatric hematologic\/oncologic patients"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6947-5894","authenticated-orcid":false,"given":"Volker","family":"Strenger","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald H.","family":"Kessler","sequence":"additional","affiliation":[{"name":"Molecular Diagnostics Laboratory Diagnostic and Research Center for Molecular Biomedicine Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Stelzl","sequence":"additional","affiliation":[{"name":"Molecular Diagnostics Laboratory Diagnostic and Research Center for Molecular Biomedicine Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan W.","family":"Aberle","sequence":"additional","affiliation":[{"name":"Center for Virology Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Keldorfer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klara","family":"Zach","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Karastaneva","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Sperl","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herwig","family":"Lackner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Benesch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans J\u00fcrgen","family":"Dornbusch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-016-2725-7"},{"key":"e_1_2_8_3_1","unstructured":"Microbiol Spectr 2016 4 3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2209.151497"},{"key":"e_1_2_8_5_1","first-page":"1","article-title":"Lamonte\u2010Fowlkes A, Oberst S, Pallansch MA, Centers for Disease C, Prevention. 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