{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:00:18Z","timestamp":1775037618202,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sickle cell disease (SCD) is the most common genetic disease in France. In developing countries, it is associated with a high incidence of hearing loss. The aim of this study was to determine the prevalence of hearing loss in French children with SCD in order to determine if they need a close audiological follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a single\u2010center prospective cross\u2010sectional study of children with SCD. The children, without specific hearing symptom, underwent an ear, nose and throat examination with a hearing assessment between 2015 and 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010nine children were included, aged from 5 to 19 years, with 73% of SS or S\u03b2<jats:sup>0<\/jats:sup> genotype and 27% of SC or S\u03b2<jats:sup>+<\/jats:sup> genotype. Ten children (11.2%) had hearing thresholds higher than 20\u00a0dB in at least one ear: one child with subnormal hearing, six otitis media with effusion (OME), and three sensorineural hearing loss. Late age at diagnosis of SCD, a high platelet count and a low hematocrit level were significantly associated with OME; moreover, children with OME had more severe clinical and biological characteristics than children with normal hearing. Furthermore, 12.4% of the children complained of tinnitus. The rate of sudden hearing loss was 2.2%. Finally, 7.1% of patients with normal hearing showed a speech discrimination disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Several causes were identified for hearing loss in children with SCD. They therefore need a close audiological follow\u2010up in order to avoid complications due to curable phenomena and to enable appropriate management for progressive complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27468","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T06:38:48Z","timestamp":1537857528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Hearing loss in children with sickle cell disease: A prospective French cohort study"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-3595","authenticated-orcid":false,"given":"Emilie","family":"Bois","sequence":"first","affiliation":[{"name":"Otolaryngology\u2010Head and Neck Surgery Department Robert Debr\u00e9 Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Francois","sequence":"additional","affiliation":[{"name":"Otolaryngology\u2010Head and Neck Surgery Department Robert Debr\u00e9 Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malika","family":"Benkerrou","sequence":"additional","affiliation":[{"name":"Sickle Cell Unit Robert Debr\u00e9 Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Van Den Abbeele","sequence":"additional","affiliation":[{"name":"Otolaryngology\u2010Head and Neck Surgery Department Robert Debr\u00e9 Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natacha","family":"Teissier","sequence":"additional","affiliation":[{"name":"Otolaryngology\u2010Head and Neck Surgery Department Robert Debr\u00e9 Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61029-X"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-198823000-00006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2012.03719.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003446-199110000-00007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016487309121507"},{"key":"e_1_2_9_7_1","first-page":"61","article-title":"Sickle cell anemia: audiological findings","volume":"1","author":"Berry RA","year":"1975","journal-title":"J. Am. Audiol. Soc."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1978.00790060024006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(98)90152-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2008.01.024"},{"key":"e_1_2_9_11_1","first-page":"235","article-title":"Hearing loss in children with sickle cell disease","volume":"55","author":"Koussi A","year":"2001","journal-title":"Acta Otorhinolaryngol Belg."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcomdis.2005.02.007"},{"key":"e_1_2_9_13_1","first-page":"285","article-title":"Sensorineural hearing loss in sickle cell disease patients in Sicily","volume":"57","author":"Samperi P","year":"2005","journal-title":"Minerva Pediatr."},{"key":"e_1_2_9_14_1","first-page":"173","article-title":"Major sickle cell anaemia and hypoacusia: about 112 cases in Yopougon, Cote d'Ivoire","volume":"102","author":"Elola A","year":"2009","journal-title":"Bull Soc Pathol Exot."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.1996.641"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1997.84.2.434"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.12.022"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70055-4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-010-0116-3"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2016.07.003"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(83)90023-0"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/26.10.1109"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-138"},{"key":"e_1_2_9_24_1","article-title":"Drug\u2010induced ototoxicity: mechanisms, pharmacogenetics, and protective strategies","author":"Lanvers\u2010Kaminsky C","year":"2016","journal-title":"Clin Pharmacol Ther."},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2016.1852"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.5214\/ans.0972.7531.1017407"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816640485"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MRR.0b013e3282fb7d4d"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.5.524"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922815594356"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-3758"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948008900409"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988209000630"},{"key":"e_1_2_9_34_1","first-page":"314","article-title":"Sensorineural hearing loss in sickle cell disease patients in Saudi Arabia","volume":"37","author":"Ashoor A","year":"1985","journal-title":"Trop Geogr Med."},{"key":"e_1_2_9_35_1","first-page":"205","article-title":"Sensorineural hearing loss in Ghanaians with sickle cell anaemia","volume":"40","author":"Atsina KK","year":"1988","journal-title":"Trop Geogr Med."},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948709600304"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003446-199110000-00008"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100124442"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(00)85001-2"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2004.05.009"},{"key":"e_1_2_9_41_1","first-page":"1135","article-title":"Hearing thresholds in sickle cell anemia patients: emerging new trends?","volume":"97","author":"Aderibigbe A","year":"2005","journal-title":"J Natl Med Assoc."},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215106001678"},{"key":"e_1_2_9_43_1","first-page":"173","article-title":"Dr\u00e9panocytose majeure et hypoacousie : \u00e0 propos de 112 cas relev\u00e9s \u00e0 Yopougon, C\u00f4te d'Ivoire","volume":"102","author":"Elola A","year":"2009","journal-title":"Bull Soc Pathol Exot."},{"key":"e_1_2_9_44_1","first-page":"306","article-title":"Hearing impairment in persons with the hemoglobin SC genotype","volume":"89","author":"Onakoya PA","year":"2010","journal-title":"Ear Nose, Throat J"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/14992020903321742"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21374"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2016.135"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.27468","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.27468","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T16:37:12Z","timestamp":1694709432000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.27468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,24]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/pbc.27468"],"URL":"https:\/\/doi.org\/10.1002\/pbc.27468","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,24]]},"assertion":[{"value":"2018-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e27468"}}