{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T21:09:31Z","timestamp":1777842571402,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Stem cell transplantation (SCT) outcomes have improved over the last three decades, with many patients being rescued with this treatment. However, improved outcomes have led to issues with long\u2010term sequelae. One of these sequelae in children is renal dysfunction, an index of which is estimated using glomerular filtration rate (eGFR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We retrospectively analyzed eGFR in 83 pediatric patients who received SCT. Data from all patients extended up to 12 months or more post SCT. The median follow\u2010up time was 127.7 months (range 12.0\u2010268.8 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen patients (21.7%) had low eGFR (&lt;90\u00a0ml\/min\/1.73 m<jats:sup>2<\/jats:sup>) post SCT. Cumulative incidence of low eGFR was 25.8 \u00b1 2.0%. Nine (10.6%) patients had a low eGFR pre\u2010SCT. However, pre\u2010 and post\u2010SCT incidence of low eGFR were not correlated. Meanwhile, only two patients (2.4%) exhibited severe renal dysfunction, with eGFRs\u00a0&lt;\u00a060\u00a0ml\/min\/1.73 m<jats:sup>2<\/jats:sup>. Independent risk factors for low eGFR were solid tumor and use of fludarabine. Moreover, age at SCT \u2265 7 years was also a long\u2010term post\u2010SCT risk factor for low eGFR in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Independent post\u2010SCT long\u2010term risk factors for low eGFR in children were solid tumor and use of fludarabine. Moreover, age at SCT \u2265 7 years was a post\u2010SCT long\u2010term risk factor for low eGFR across all patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27478","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T11:57:16Z","timestamp":1540295836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Long\u2010term outcome of renal function in children after stem cell transplantation measured by estimated glomerular filtration rate"],"prefix":"10.1002","volume":"66","author":[{"given":"Yukayo","family":"Ukeba\u2010Terashita","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kushiro Red Cross Hospital  Kushiro Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3937-0856","authenticated-orcid":false,"given":"Ryoji","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology for Children and Adolescents Sapporo Hokuyu Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0634-6961","authenticated-orcid":false,"given":"Daiki","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology for Children and Adolescents Sapporo Hokuyu Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Matsushima","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology for Children and Adolescents Sapporo Hokuyu Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4183-4602","authenticated-orcid":false,"given":"Hirozumi","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology for Children and Adolescents Sapporo Hokuyu Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology for Children and Adolescents Sapporo Hokuyu Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahide","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Asahikawa City Hospital  Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Obihiro\u2010Kosei General Hospital  Obihiro Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michihiko","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nikko Memorial Hospital  Muroran Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hakodate Goryokaku Hospital  Hakodate Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology for Children and Adolescents Sapporo Hokuyu Hospital  Sapporo 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