{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:14:36Z","timestamp":1785521676874,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T00:00:00Z","timestamp":1539475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1701418N"],"award-info":[{"award-number":["1701418N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Physical fitness is an important determinant of quality of life (QOL) after hematopoietic stem cell transplantation. Cardiac function can influence exercise performance. The aim of this study was to assess these factors and their interrelationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Children underwent cardiopulmonary exercise testing (CPET) at least 1 year after hematopoietic stem cell transplantation (HSCT) and were compared with healthy controls. Systolic and diastolic heart function and left ventricle (LV) wall dimensions were measured. Health\u2010related QOL (HR\u2010QOL) was evaluated using PedsQL questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010three patients performed CPET (26 boys, 13.6\u00a0\u00b1\u00a03.4\u00a0years, weight 45.5\u00a0\u00b1\u00a013.3\u00a0kg, length 152.9\u00a0\u00b1\u00a017.5\u00a0cm, body surface area 1.35\u00a0\u00b1\u00a00.28). HSCT patients had lower maximal oxygen consumption (VO2peak\/kg, 34.7\u00a0\u00b1\u00a08.4\u00a0vs 46.3\u00a0\u00b1\u00a07.1\u00a0mL\/kg\/min, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), shorter exercise duration (9.1\u00a0\u00b1\u00a02.5\u00a0vs 12.9\u00a0\u00b1\u00a02.6\u00a0min, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and lower maximal load (%Ppeak 70.8\u00a0\u00b1\u00a019.7\u00a0vs 102.4%\u00a0\u00b1\u00a015.9%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Echocardiography demonstrated decreased interventricular septal wall thickness (interventricular septum in diastole [IVSd] <jats:italic>Z<\/jats:italic>\u2010value \u22120.64\u00a0\u00b1\u00a00.69, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and more systolic (11% of patients) and diastolic dysfunction (high <jats:italic>E<\/jats:italic>\/<jats:italic>E<\/jats:italic>\u2019 <jats:italic>Z<\/jats:italic>\u2010value 1.06\u00a0\u00b1\u00a01.13, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). LV dilatation correlates with VO2max\/kg (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.364, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.017). HR\u2010QOL showed lower overall and emotional functioning scores (respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.016 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Patients after anthracycline therapy have the lowest maximal exercise performance, but have no difference in QOL. Diminished exercise performance is not encountered as a QOL limitation. Total body irradiation influences the domain of psychosocial functioning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LV (systolic and diastolic) and right ventricle dysfunctions justify the need for thorough cardiac follow\u2010up in children after HSCT. Lower physical fitness levels and lower HR\u2010QOL emphasize the importance of CPET and fitness programs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27499","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T04:51:06Z","timestamp":1539579066000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Evaluation of cardiopulmonary exercise testing, heart function, and quality of life in children after allogenic hematopoietic stem cell transplantation"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1481-0878","authenticated-orcid":false,"given":"Kristof","family":"Vandekerckhove","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"De Waele","sequence":"additional","affiliation":[{"name":"Department of 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