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One patient (10%) with Beckwith\u2010Wiedemann syndrome developed a new tumor, without anaplasia. There were no significant toxicities reported during maintenance. All patients are currently alive with no evidence of disease. Further investigations are recommended to determine the utility of this approach.<\/jats:p>","DOI":"10.1002\/pbc.27500","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T09:50:56Z","timestamp":1539856256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Maintenance chemotherapy to reduce the risk of a metachronous Wilms tumor in children with bilateral nephroblastomatosis"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9379-314X","authenticated-orcid":false,"given":"Michael V.","family":"Ortiz","sequence":"first","affiliation":[{"name":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon","family":"Fernandez\u2010Ledon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavitha","family":"Ramaswamy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Forlenza","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2516-2965","authenticated-orcid":false,"given":"Neerav N.","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Kobos","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York City New York"},{"name":"Janssen Pharmaceuticals  Raritan New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3515-0028","authenticated-orcid":false,"given":"Todd E.","family":"Heaton","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York City New York"},{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center  New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"LaQuaglia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York City New York"},{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center  New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G.","family":"Steinherz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950210303"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/15513819009067094"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26547"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20891"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-0710"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1371840"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20386"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002356"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990401)85:7<1616::AID-CNCR26>3.0.CO;2-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-018-0686-z"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-10-136"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181979c70"}],"container-title":["Pediatric Blood &amp; 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