{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:03:28Z","timestamp":1791583408248,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T00:00:00Z","timestamp":1542153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Deutsche Krebshilfe e. V., European Executive Agency for Health and Consumers"},{"name":"Mitteldeutsche Kinderkrebsforschung - Stiftung f\u00fcr Forschung und Heilung"},{"name":"Menschen f\u00fcr Kinder e. V. and Tour der Hoffnung - Helping Hands for children e. V"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>In 2014, we published the qPET method to quantify fluorodeoxyglucose positron emission tomography (FDG\u2010PET) responses. Analysis of the distribution of the quantified signals suggested that a clearly abnormal FDG\u2010PET response corresponds to a visual Deauville score (vDS) of 5 and high qPET values \u2265 2. Evaluation in long\u2010term outcome data is still pending. Therefore, we analyzed progression\u2010free survival (PFS) by early FDG\u2010PET response in a subset of the GPOH\u2010HD2002 trial for pediatric Hodgkin lymphoma (PHL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Pairwise FDG\u2010PET scans for initial staging and early response assessment after two cycles of chemotherapy were available in 93 PHL patients. vDS and qPET measurement were performed and related to PFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with a qPET value \u2265 2.0 or vDS of 5 had 5\u2010year PFS rates of 44%, respectively 50%. Those with qPET values\u00a0&lt;\u00a02.0 or vDS 1 to 4 had 5\u2010year PFS rates of 90%, respectively 80%. The positive predictive value of FDG\u2010PET response assessment increased from 18% (9%; 33%) using a qPET threshold of 0.95 (vDS \u2264 3) to 30% (13%; 54%) for a qPET threshold of 1.3 (vDS \u2264 4) and to 56% (23%; 85%) when the qPET threshold was \u2265 2.0 (vDS 5). The negative predictive values remained stable at \u226592% (CI: 82%; 98%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Only strongly enhanced residual FDG uptake in early response PET (vDS 5 or qPET \u2265 2, respectively) seems to be markedly prognostic in PHL when treatment according to the GPOH\u2010HD\u20102002 protocol is given.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27539","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T08:08:41Z","timestamp":1542182921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Only strongly enhanced residual FDG uptake in early response PET (Deauville 5 or qPET \u2265 2) is prognostic in pediatric Hodgkin lymphoma: Results of the GPOH\u2010HD2002 trial"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3396-4880","authenticated-orcid":false,"given":"L.","family":"Kurch","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine University Hospital of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Hasenclever","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics Informatics and Epidemiology University of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kluge","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Georgi","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital of Leipzig  Leipzig 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Brenner","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.W.","family":"Sykora","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Medizinische Hochschule Hannover  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.M.","family":"Bengel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Medizinische Hochschule Hannover  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8672-5285","authenticated-orcid":false,"given":"C.","family":"Rossig","sequence":"additional","affiliation":[{"name":"University Children's Hospital M\u00fcnster Pediatric Hematology and Oncology  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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.A.","family":"Ammann","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics (Inselspital) Bern University Hospital University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Krause","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Inselspital Bern University Hospital University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Urban","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics University Hospital Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Aigner","sequence":"additional","affiliation":[{"name":"Department of Radiology Medical University Graz  Graz 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