{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T22:11:33Z","timestamp":1791756693778,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A thorough understanding of local and contemporary invasive fungal infection (IFI) epidemiology in immunocompromised children is required to provide a rationale for targeted prevention and treatment strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective data over 10\u00a0years from four tertiary pediatric oncology and hematopoietic stem cell transplant (HSCT) units across Australia were analyzed to report demographic, clinical, and mycological characteristics of IFI episodes, and crude IFI prevalence in select oncology\/HSCT groups. Kaplan\u2013Meier survival analyses were used to calculate 180\u2010day overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 337 IFI episodes occurred in 320 children, of which 149 (44.2%), 51 (15.1%), and 110 (32.6%) met a modified European Organization for Research and Treatment of Cancer (mEORTC) criteria for proven, probable, and possible IFI, respectively. There were a further 27 (8.0%) that met a \u201cmodified possible IFI\u201d criteria. Median age at IFI diagnosis was 8.4\u00a0years. Crude mEORTC IFI prevalence in acute lymphoblastic leukemia, acute myeloid leukemia, solid tumor, and allogeneic HSCT cohorts was 10.6%, 28.2%, 4.4%, and 11.7%, respectively. Non\u2010\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      species represented 48\/102 (47.1%) molds identified, and non\u2010\n                      <jats:italic>albicans Candida<\/jats:italic>\n                      represented 66\/93 (71.0%) yeasts identified. There were 56 deaths among 297 children who met mEORTC criteria, with 180\u2010day overall survival for proven, probable, and possible IFIs of 79.7%, 76.2%, and 84.4%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Non\u2010\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      molds and non\u2010albicans\n                      <jats:italic>Candida<\/jats:italic>\n                      contributed substantially to pediatric IFI in our study, with high IFI prevalence in leukemia and allogeneic HSCT cohorts. Inclusion of IFIs outside of European Organization for Research and Treatment of Cancer criteria revealed an IFI burden that would go otherwise unrecognized in published reports.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.27564","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T04:28:11Z","timestamp":1543897691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Epidemiology of invasive fungal infections in immunocompromised children; an Australian national 10\u2010year review"],"prefix":"10.1002","volume":"66","author":[{"given":"Adam W.","family":"Bartlett","sequence":"first","affiliation":[{"name":"Department of Immunology and Infectious Diseases Sydney Children's Hospital  Randwick NSW Australia"},{"name":"School of Women's and Children's Health UNSW  Sydney Australia"},{"name":"Biostatistics and Databases Program Kirby Institute 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Oncology Princess Margaret Hospital for Children  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Blyth","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Princess Margaret Hospital for Children  Perth Western Australia Australia"},{"name":"Department of Microbiology PathWest Laboratory Medicine  Western Australia Australia"},{"name":"Telethon Kids Institute University of Western Australia  Perth Western Australia Australia"},{"name":"School of Medicine University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi S.","family":"Kotecha","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology Princess Margaret Hospital for Children  Perth Western Australia Australia"},{"name":"Telethon Kids Institute University of Western Australia  Perth Western Australia Australia"},{"name":"School of Medicine University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan J.","family":"McMullan","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases Sydney Children's Hospital  Randwick NSW Australia"},{"name":"School of Women's and Children's Health UNSW  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Oncology Lady Cilento Children's Hospital Children's Health Queensland  South Brisbane Australia"},{"name":"Infection Management Service Lady Cilento Children's Hospital Children's Health Queensland  South Brisbane Queensland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle M.","family":"Haeusler","sequence":"additional","affiliation":[{"name":"The Paediatric Integrated Cancer Service  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