{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T03:46:33Z","timestamp":1772250393300,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic myeloid leukemia (CML) is a rare disease in children. Different from that in adults, childhood CML involves transformative events occurring over a short time period. CML transformation to lymphoid blast phase (BP) is associated with copy number abnormalities, characteristic of BCR\u2010ABL1 positive acute lymphoblastic leukemia, but not of CML in the chronic phase. Here, we present an unusual case of CML progressing to BP in a 1.6\u2010year\u2010old child, harboring <jats:italic>IKZF1<\/jats:italic>, <jats:italic>PAX5<\/jats:italic>, <jats:italic>CDKN2A<\/jats:italic>, and <jats:italic>ETV6<\/jats:italic> deletions at diagnosis. It remains to be addressed whether distinct mechanisms might account for CML pathogenesis in early childhood.<\/jats:p>","DOI":"10.1002\/pbc.27570","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T09:27:50Z","timestamp":1543915670000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>IKZF1<\/i> deletion and co\u2010occurrence with other aberrations in a child with chronic myeloid leukemia progressing to acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"66","author":[{"given":"Claudete Esteves","family":"Klumb","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Hemato\u2010Oncologia Celular e Molecular Programa de Pesquisa em Hemato\u2010Oncologia Molecular, Instituto Nacional de C\u00e2ncer (INCA)  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thayana da Concei\u00e7\u00e3o","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Grupo de Estudo em C\u00e2ncer Molecular Divis\u00e3o de Pesquisa Cl\u00ednica INCA  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Nestal de Moraes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Hemato\u2010Oncologia Celular e Molecular Programa de Pesquisa em Hemato\u2010Oncologia Molecular, Instituto Nacional de C\u00e2ncer (INCA)  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia Trindade","family":"Schramm","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Hematologia Hospital do C\u00e2ncer I INCA  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2337-8420","authenticated-orcid":false,"given":"Mariana","family":"Emerenciano","sequence":"additional","affiliation":[{"name":"Grupo de Estudo em C\u00e2ncer Molecular Divis\u00e3o de Pesquisa Cl\u00ednica INCA  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0225-471X","authenticated-orcid":false,"given":"Raquel Ciuvalschi","family":"Maia","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Hemato\u2010Oncologia Celular e Molecular Programa de Pesquisa em Hemato\u2010Oncologia Molecular, Instituto Nacional de C\u00e2ncer (INCA)  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/300765a0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-06-648667"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2014.09.008"},{"key":"e_1_2_7_5_1","first-page":"3310","article-title":"Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL\u2010BFM 90. German\u2010Austrian\u2010Swiss ALL\u2010BFM Study Group","volume":"95","author":"Schrappe M","year":"2000","journal-title":"Blood"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199310283291801"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2015.06.003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0179-9"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2367-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-380774"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.21989"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30767"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.298"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.99"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06866"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2017.11.005"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12812"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12850"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2012.05.007"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.20.17779"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05690"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21076"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-366542"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.27570","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.27570","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T18:13:04Z","timestamp":1694715184000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.27570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,4]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1002\/pbc.27570"],"URL":"https:\/\/doi.org\/10.1002\/pbc.27570","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,4]]},"assertion":[{"value":"2018-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e27570"}}