{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:21:14Z","timestamp":1787505674424,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA21765"],"award-info":[{"award-number":["CA21765"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treating B\u2013non\u2010Hodgkin lymphoma (B\u2010NHL) in lower\u2010income countries is challenging because of imprecise diagnosis, the increased risk of fatal toxicity associated with advanced disease at presentation, and limited supportive care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>Central American patients with newly diagnosed stage I or II B\u2010NHL received a modified Berlin\u2013Frankfurt\u2013M\u00fcnster (BFM) regimen including a prephase (prednisone, cyclophosphamide) followed by A\/B\/A courses (A: cytarabine, dexamethasone, etoposide, ifosfamide, methotrexate, and intrathecal therapy; B: cyclophosphamide, dexamethasone, doxorubicin, methotrexate, and intrathecal therapy). Those with stage III or IV NHL received additional courses (B\/A\/B), intensified for stage IV disease by additional vincristine and methotrexate doses. Patients in poor condition received a second prephase treatment before their chemotherapy courses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between March 2004 and June 2016, of 405 patients with B\u2010NHL, 386 (109 females) were eligible for treatment. Immunohistochemistry was performed in 177 cases (47.4%) and characterized the disease as mature B\u2010cell lymphoma. Stage distribution was as follows: I\/II, 31 (8.1%); III, 252 (65.3%); IV, 93 (24.1%); 10 (2.6%) not available. The 3\u2010year overall survival was 70% for the whole group (86% for stages I\/II, 75% for stage III, 58% for stage IV). Events included death during induction (34 patients, 8.8%), relapse\/progression (46, 11.9%), death in remission (9, 2.3%), second malignancy (1, 0.26%), and death of unknown cause (1, 0.26%). Twenty\u2010three (6%) patients abandoned or refused therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Approximately 70% of children with B\u2010NHL from Central America experienced long\u2010term, disease\u2010free survival with a modified BFM schedule. Toxic death and relapse\/resistant disease were the main reasons for treatment failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.27621","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T18:34:08Z","timestamp":1548354848000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Outcome of pediatric non\u2010Hodgkin lymphoma in Central America: A report of the Association of Pediatric Hematology Oncology of Central America (AHOPCA)"],"prefix":"10.1002","volume":"66","author":[{"given":"Armando","family":"Pe\u00f1a\u2010Hernandez","sequence":"first","affiliation":[{"name":"Department of Pediatric Hemato\u2010Oncology Hospital Escuela\u2010Universitario  Tegucigalpa Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Manuel de J\u00e9sus Rivera Hospital  Managua Nicaragua"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Garrido","sequence":"additional","affiliation":[{"name":"National Pediatric Oncology Unit Francisco Marroqu\u00edn University Medical School  Guatemala City Guatemala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Gomez\u2010Garcia","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2010Oncology Dr. Robert Reid Cabral Children's Hospital  Santo Domingo Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soad","family":"Fuentes\u2010Alabi","sequence":"additional","affiliation":[{"name":"Department of Onco\u2010Hematology Hospital Benjamin Bloom  San Salvador El Salvador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Martinez","sequence":"additional","affiliation":[{"name":"Hemato\u2010Oncology Service Hospital Mario Catarino Rivas  San Pedro Sula Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika L.","family":"Metzger","sequence":"additional","affiliation":[{"name":"Department of Oncology Leukemia\/Lymphoma Division and Global Pediatric Medicine Program St. Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9375-9336","authenticated-orcid":false,"given":"Guillermo L.","family":"Chantada","sequence":"additional","affiliation":[{"name":"Hospital de Pediatr\u00eda (SAMIC) Prof. Dr. Juan P. Garrahan  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul C.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Oncology Leukemia\/Lymphoma Division and Global Pediatric Medicine Program St. Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.5827"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199705)28:5<333::AID-MPO2>3.0.CO;2-I"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20116"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21452"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14030"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24407"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31826226b1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2012.03.006"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-9378-9-19"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61177-X"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70139-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30170"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2011.644881"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181e90017"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2006.00735.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-012-1491-5"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20989"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24905"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25698"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.2.186"},{"key":"e_1_2_8_22_1","first-page":"3294","article-title":"Improved treatment results in childhood B\u2010cell neoplasms with tailored intensification of therapy: a report of the Berlin\u2010Frankfurt\u2010Munster Group Trial NHL\u2010BFM 90","volume":"94","author":"Reiter A","year":"1999","journal-title":"Blood"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11899-006-0004-9"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200407000-00014"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22905"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-7563.2009.01264.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.60.6376"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-0973"},{"key":"e_1_2_8_29_1","first-page":"CD003039","article-title":"Colony\u2010stimulating factors for chemotherapy\u2010induced febrile neutropenia","author":"Mhaskar R","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1081\/CNV-120002487"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.6791"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31829d4900"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24534"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.121434"}],"container-title":["Pediatric Blood &amp; 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