{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:09:19Z","timestamp":1790291359141,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Noonan syndrome (NS) is an autosomal dominant disorder commonly caused by <jats:italic>PTPN11<\/jats:italic> germline mutations. Patients are characterized by short stature, congenital heart defects, facial dysmorphism, and increased risk of malignancies including brain tumors. Commonly associated brain tumors are dysembryoplastic neuroepithelial tumor and low\u2010grade glioma. We report two cases of anaplastic astrocytoma with <jats:italic>PTPN11<\/jats:italic>\u2010related NS. We conducted a systematic search of medical databases looking for other reported cases of high\u2010grade glioma associated with NS and identified 24 cases of brain tumors, all of which were low\u2010grade glial or glioneuronal tumors except for one case of medulloblastoma.<\/jats:p>","DOI":"10.1002\/pbc.27625","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T05:44:35Z","timestamp":1548740675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Occurrence of high\u2010grade glioma in Noonan syndrome: Report of two cases"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9791-0104","authenticated-orcid":false,"given":"Moatasem","family":"El\u2010Ayadi","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics and Adolescent Medicine University Hospital of Geneva  Geneva Switzerland"},{"name":"Department of Pediatrics CANSEARCH Research Laboratory Faculty of Medicine University of Geneva  Geneva Switzerland"},{"name":"Department of Pediatric Oncology National Cancer Institute Cairo University  Giza Egypt"},{"name":"Department of Pediatric Oncology Children's Cancer Hospital  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Ansari","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics and Adolescent Medicine University Hospital of Geneva  Geneva Switzerland"},{"name":"Department of Pediatrics CANSEARCH Research Laboratory Faculty of Medicine University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caspar D.","family":"K\u00fchn\u00f6l","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology University Hospital Halle Clinic and Polyclinic for Pediatrics I Faculty of Medicine Martin\u2010Luther\u2010University Halle\u2010Wittenberg  Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2062-0974","authenticated-orcid":false,"given":"Anne","family":"Bendel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology Children's Minnesota  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Sturm","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurooncology German Cancer Research Center (DKFZ) Hopp\u2010Children's Cancer Center at the NCT Heidelberg German Consortium for Translational Cancer Research (DKTK)  Heidelberg Germany"},{"name":"Department of Pediatric Oncology Hematology Immunology and Pulmonology Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Pietsch","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology DGNN Brain Tumor Reference Center University of Bonn Medical Center  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof M.","family":"Kramm","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology University Medical Center Goettingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4197-6264","authenticated-orcid":false,"given":"Andr\u00e9 O.","family":"von Bueren","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics and Adolescent Medicine University Hospital of Geneva  Geneva Switzerland"},{"name":"Department of Pediatrics CANSEARCH Research Laboratory Faculty of Medicine University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1968.02100020377005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng772"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1156"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12568"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.75"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38108"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature26000"},{"key":"e_1_2_7_9_1","unstructured":"BendelA PondD.Case Report of central nervous system (CNS) neoplasms in three individuals with Noonan syndrome (NS) and PTPN11 mutation and a review of the literature.16th International Symposium on Pediatric Neuro\u2010Oncology Poster Presentation 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