{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T18:19:39Z","timestamp":1773685179104,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T00:00:00Z","timestamp":1549756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hematopoietic stem cell transplant (HSCT) can cure or alleviate a wide range of nonmalignant childhood conditions. However, few studies have examined longitudinal national trends of frequency or short\u2010term complications of HSCT before 2006 when an HSCT became a reportable procedure by US law. By using a US nationally representative database, we conducted nationwide longitudinal analyses on demographics, in\u2010hospital mortality, and short\u2010term complications in nonmalignant HSCT from 2000 to 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We analyzed 2504 admissions for children &lt;\u00a020\u00a0years old who underwent an allogeneic HSCT for a nonmalignant condition by using the Kids' Inpatient Database for the years 2000, 2003, 2006, 2009, and 2012. Changes in in\u2010hospital mortality and other outcomes were assessed over the study period using weighted analyses, which enabled generation of national estimates in each year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of admissions for HSCT increased from 334 to 667 from 2000 to 2012, respectively; among them, the use of bone marrow decreased (66.5% to 34.1%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In\u2010hospital mortality declined (13.4% to 7.1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04), as did bacteremia (28.7% to 10.1%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and vascular catheter infections (18.8% to 8.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006), but cytomegalovirus infections increased (4.9% to 15.9%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), as did adenovirus infections (1.8% to 6.9%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) from 2000 to 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Population\u2010based analyses demonstrated a substantial expansion of the utilization of HSCT occurred for pediatric nonmalignancies from 2000 to 2012 in the United States, whereas the in\u2010hospital mortality declined by approximately a half. Further research is needed to identify distinct contributing factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27626","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T07:46:07Z","timestamp":1549871167000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["In\u2010hospital mortality of hematopoietic stem cell transplantation among children with nonmalignancies: A nationwide study in the United States from 2000 to 2012"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8296-6412","authenticated-orcid":false,"given":"Takuto","family":"Takahashi","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology Department of Pediatrics University of Minnesota  Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Pereda","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Pediatrics Rainbow Babies and Children's Hospital  Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Bala","sequence":"additional","affiliation":[{"name":"Department of Pediatrics SUNY Downstate Medical Center  Brooklyn New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sairaman","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology Department of Pediatrics SUNY Downstate Medical Center  Brooklyn New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)92673-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.05.017"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.10.001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0B013E318161FAC1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-014-1577-z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23281"},{"key":"e_1_2_8_8_1","unstructured":"HCUP Sample Design: National Databases[database online].https:\/\/www.hcup-us.ahrq.gov\/tech_assist\/sampledesign\/508_compliance\/508course.htm. Accessed September 13 2018."},{"key":"e_1_2_8_9_1","unstructured":"Clinical Classifications Software (CCS) 2015[database online].https:\/\/www.hcup-us.ahrq.gov\/toolssoftware\/ccs\/CCSUsersGuide.pdf. Accessed September 13 2018."},{"key":"e_1_2_8_10_1","unstructured":"Introduction to the HCUP Kids\u2019 Inpatient Database (KID) 2012[database online].https:\/\/www.hcup-us.ahrq.gov\/db\/nation\/kid\/kid_2012_introduction.jsp. Accessed September 13 2018."},{"key":"e_1_2_8_11_1","unstructured":"Center for International Blood and Marrow Transplant a contractor for the C.W. Bill Young Cell Transplantation Program operated through the U.S. Department of Health and Human Services Health Resources and Services Administration Healthcare Systems Bureau. Transplant Activity Report. Number of HCTs performed in the United States and reported to CIBMTR by year and specific disease 2010\u20102014.https:\/\/bloodcell.transplant.hrsa.gov\/research\/transplant_data\/transplant_activity_report\/year-specific_disease.pdf. Accessed September 13 2018."},{"key":"e_1_2_8_12_1","unstructured":"Producing National HCUP Estimates[webpage].https:\/\/www.hcup-us.ahrq.gov\/tech_assist\/nationalestimates\/508_course\/508course.jsp. Accessed September 13 2018."},{"key":"e_1_2_8_13_1","unstructured":"Data Use Agreement for the Nationwide Databases[database online].https:\/\/www.hcup-us.ahrq.gov\/team\/NationwideDUA.pdf. Accessed September 13 2018."},{"key":"e_1_2_8_14_1","unstructured":"D'Souza AFC.Current uses and outcomes of hematopoietic cell transplantation (HCT): CIBMTR summary slides;2016[webpage].http:\/\/www.cibmtr.org\/. Accessed September 13 2018."},{"key":"e_1_2_8_15_1","first-page":"1918","article-title":"Impact of bone marrow transplantation for symptomatic sickle cell disease: an interim report. Multicenter investigation of bone marrow transplantation for sickle cell disease","volume":"95","author":"Walters MC","year":"2000","journal-title":"Blood"},{"key":"e_1_2_8_16_1","unstructured":"The Management of Sickle Cell Disease. 4th ed. 2002.NIH[webpage].https:\/\/www.nhlbi.nih.gov\/files\/docs\/guidelines\/sc_mngt.pdf. Accessed September 13 2018."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1401177"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-455238"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-745711"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3182677f35"},{"issue":"10","key":"e_1_2_8_21_1","first-page":"1","article-title":"Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients","volume":"49","year":"2000","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_8_22_1","unstructured":"NMDP\/Be The Match and ASBMT Recommended Timing for Transplant Consultation;2016[webpage].https:\/\/bethematchclinical.org\/workarea\/downloadasset.aspx?id=3545. Accessed September 13 2018."},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13059"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811263392201"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fdr054"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.27626","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.27626","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pbc.27626","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.27626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T21:01:14Z","timestamp":1694379674000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.27626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,10]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/pbc.27626"],"URL":"https:\/\/doi.org\/10.1002\/pbc.27626","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,10]]},"assertion":[{"value":"2018-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e27626"}}