{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T22:33:11Z","timestamp":1785277991332,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Since the beginning of the Syrian civil war, more than 3.5 million Syrians have been under temporary protection status in Turkey. Because beta\u2010thalassemia (BT) is a prevalent disorder in the Mediterranean countries, we decided to estimate the prevalence of and make an overview of the demographic, socioeconomic, medical characteristics, and healthcare problems of refugee children with BT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Eighteen Turkish Pediatric Hematology Oncology Centers (PHOC) with 318 refugee children from 235 families participated in the study. The mean age of the patients was 8.1\u00a0\u00b1\u00a04.8\u00a0years (0.5\u201321\u00a0years). The mean time after immigration to Turkey was 2.5\u00a0\u00b1\u00a01.5\u00a0years (range, 0.1\u20137\u00a0years). Seventy\u2010two (22.6%) of them were born and diagnosed with BT in Turkey. On physical examination, 82 patients (26%) were underweight and 121 patients (38%) were stunted. The appearance of a thalassemic face was reported for 207 patients (65.1%). Hepatomegaly and splenomegaly were reported in 217 (68.2%) and 168 (52.8%) patients, respectively. The median ferritin level was 2508\u00a0ng\/mL (range, 17\u201321\u00a0000\u00a0ng\/mL) at the first admission, and 2841\u00a0ng\/mL (range, 26\u201312\u00a0981\u00a0ng\/mL) at the last visit after two years of follow\u2010up in a PHOC (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). The most frequently encountered mutation was IVSI\u2010110 (G&gt;A) (31%). Before immigration, only 177 patients (55.6%) reported the use of chelators; after immigration it increased to 268 (84.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Difficulties in communication, finding a competent translator capable in medical terminology, nonregular use of medications, and insensitivity to prenatal diagnosis were preliminary problems. The current extent of migration poses emerging socioeconomic and humanitarian challenges for refugee patients with BT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27636","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T15:12:01Z","timestamp":1549033921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Refugee children with beta\u2010thalassemia in Turkey: Overview of demographic, socioeconomic, and medical characteristics"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1043-8471","authenticated-orcid":false,"given":"Arzu","family":"Yazal Erdem","sequence":"first","affiliation":[{"name":"Pediatric Hematology and Oncology, University of Health Sciences Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Demir 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Tekg\u00fcnd\u00fcz","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Ke\u00e7i\u00f6ren Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do\u011fan","family":"K\u00f6se","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Diyarbak\u0131r Children's Hospital Diyarbak\u0131r Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuba","family":"Karap\u0131nar","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology \u0130zmir Dr Beh\u00e7et Uz Children Training and Research Hospital \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"B\u00fcy\u00fckavc\u0131","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Sakarya University Faculty of Medicine Sakarya 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