{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T13:45:14Z","timestamp":1769435114775,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sickle cell disease (SCD) is a chronic multisystem disorder requiring comprehensive care that includes newborn screening (NBS) as the first step of care. Italy still lacks a national SCD NBS program and policy on blood disorders. Pilot single\u2010center screening programs and a regional targeted screening have been implemented so far, but more evidence is needed in order to impact health policies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population and methods<\/jats:title><jats:p>NBS was offered to parents of newborns in gynecology clinics in Padova and Monza, tertiary care university hospitals in northern Italy. High\u2010performance liquid chromatography (HPLC) was performed as the first test on samples collected on Guthrie cards. Molecular analysis of the beta\u2010globin gene was performed on positive samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 5466 newborns were enrolled; for 5439, informed consents were obtained. A similar family origin was seen in the two centers (65% Italians, 9% mixed couples, 26% immigrants). Compared with SCD NBS programs in the United States and Europe, our results show a similar incidence of SCD patients and carriers. All SCD patients had a Sub\u2010Saharan family background; HbS carriers were 15% Caucasians (Italian, Albanians) and 10% from other areas (North Africa\u2013India\u2013South America); carriers of other hemoglobin variants were mainly (47%) from other areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results demonstrate the feasibility of a multicentric NBS program for SCD, give information on HbS epidemiology in two Northern Italian Areas, and support previous European recommendation for a universal NBS program for SCD in Italy: a high incidence of patients and carriers has been detected, with a high percentage of Caucasian carriers, impossible to identify in a targeted NBS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27657","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T04:16:06Z","timestamp":1549426566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Results of a multicenter universal newborn screening program for sickle cell disease in Italy: A call to action"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9797-0457","authenticated-orcid":false,"given":"Raffaella","family":"Colombatti","sequence":"first","affiliation":[{"name":"Clinic of Pediatric Hematology Oncology Department of Woman's and Child Health Azienda Ospedaliera\u2010Universit\u00e0 di Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maddalena","family":"Martella","sequence":"additional","affiliation":[{"name":"Clinic of Pediatric Hematology Oncology Department of Woman's and Child Health Azienda Ospedaliera\u2010Universit\u00e0 di Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\u2010Universit\u00e0 di Mitlano Bicocca Fondazione MBBM  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampietro","family":"Viola","sequence":"additional","affiliation":[{"name":"Clinic of Pediatric Hematology Oncology Department of Woman's and Child Health Azienda Ospedaliera\u2010Universit\u00e0 di Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Cappellari","sequence":"additional","affiliation":[{"name":"Clinic of Pediatric Hematology Oncology Department of Woman's and Child Health Azienda Ospedaliera\u2010Universit\u00e0 di Padova  Padova 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