{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:31:33Z","timestamp":1792168293277,"version":"4.4.0"},"reference-count":67,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:00:00Z","timestamp":1551312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000015","name":"Canadian Cancer Society Research Institute","doi-asserted-by":"publisher","award":["704448"],"award-info":[{"award-number":["704448"]}],"id":[{"id":"10.13039\/501100000015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>For parents, a diagnosis of cancer in their child is a traumatic experience. However, there is conflicting evidence about the risk of developing mental illness among parents following diagnosis. Our objective was to conduct a meta\u2010analysis to determine the prevalence of mental illness in parents of children with cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four databases were searched to identify articles describing the prevalence of anxiety, depression, or posttraumatic stress disorder (PTSD) in parents of pediatric cancer patients. Two reviewers independently screened and extracted data. Subgroup analyses by gender and phase of cancer experience were selected a priori. Studies were reviewed in accordance with PRISMA guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 11\u00a0394 articles identified, 58 met inclusion criteria. Reported prevalence was highly heterogeneous, ranging from 5% to 65% for anxiety (pooled prevalence 21% [95% CI, 13%\u201335%]), 7% to 91% for depression (pooled prevalence 28% [95% CI, 23%\u201335%]), and 4% to 75% for PTSD (pooled prevalence 26% [95% CI, 22%\u201332%]). Prevalence was consistently higher than noncancer parental controls. Heterogeneity was not explained by parental gender or child's cancer phase and was instead likely due to significant methodological differences in measurement tools and defined thresholds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Parents of children with cancer have a higher prevalence of anxiety, depression, and PTSD compared with population controls. Yet, the reported prevalence of mental illness was highly variable, hampering any conclusive findings on absolute prevalence. To better understand the risk of long\u2010term mental illness in this population and target interventions, future studies must adhere to standardized reporting and methods.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.27677","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T03:10:40Z","timestamp":1551323440000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":202,"title":["Prevalence of anxiety, depression, and posttraumatic stress disorder in parents of children with cancer: A meta\u2010analysis"],"prefix":"10.1002","volume":"66","author":[{"given":"Jacqui","family":"van Warmerdam","sequence":"first","affiliation":[{"name":"The Hospital for Sick Children Research Institute Child Health and Evaluative Sciences  Toronto Canada"},{"name":"University of Toronto Institute of Medical Sciences  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veda","family":"Zabih","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children Research Institute Child Health and Evaluative Sciences  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kurdyak","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health CAMH Institute for Mental Health Policy Research  Toronto Canada"},{"name":"ICES Cancer  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinku","family":"Sutradhar","sequence":"additional","affiliation":[{"name":"ICES Cancer  Toronto Canada"},{"name":"University of Toronto Institute of Health Policy Management and Evaluation  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0334-0871","authenticated-orcid":false,"given":"Paul C.","family":"Nathan","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children Research Institute Child Health and Evaluative Sciences  Toronto Canada"},{"name":"ICES Cancer  Toronto Canada"},{"name":"University of Toronto Institute of Health Policy Management and Evaluation  Toronto Canada"},{"name":"The Hospital for Sick Children Division of Hematology\/Oncology  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1334-3670","authenticated-orcid":false,"given":"Sumit","family":"Gupta","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children Research Institute Child Health and Evaluative Sciences  Toronto Canada"},{"name":"ICES Cancer  Toronto Canada"},{"name":"University of Toronto Institute of Health Policy Management and Evaluation  Toronto Canada"},{"name":"The Hospital for Sick Children Division of Hematology\/Oncology  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002820-200601000-00010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-3729.2002.00103.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.761"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0897-1897(03)00054-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/008124631004000313"},{"key":"e_1_2_8_7_1","unstructured":"American Psychiatric Association.DSM\u2010IV\u2010TR. 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