{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:42:40Z","timestamp":1791538960519,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T00:00:00Z","timestamp":1551052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Information regarding the incidence and patterns of childhood malignancies is disproportionately overrepresented by high\u2010income countries, representing mainly the Caucasian population. There is a need to evaluate and disseminate information for other ethnicities, particularly from the Middle East.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from the National Cancer Registry, Saudi Arabia (SA\u2010NCR), for pediatric patients (age 0\u201314 years) diagnosed between 2005 and 2009 and for similar patients at our institution during the same period were analyzed. Population numbers reported in the 2007 national census were used to calculate the annual incidence of childhood cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from SA\u2010NCR on 3885 patients were included in this analysis. The median age was 5.58 years, and 57.3% were males. The annual age\u2010specific cancer incidence rate (ASR) for children in SA is 99.83 per million population; ASR per million for lymphoid leukemia is 25.75, 12.05 for brain tumors, and 9.82 for Hodgkin lymphoma. Of all childhood cancers in SA, 35% were treated at our institution. The five\u2010year overall survival for these 1350 patients is 74.6% (median follow\u2010up 7.52 years [95% confidence interval: 7.36\u20137.68]). Significant differences in the distribution of childhood malignancy subtypes were evident compared with other countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We have reported differences in the cancer ASR and cancer subtype distribution for children in SA as compared with the worldwide incidence and with other populations. This paper provides a comprehensive epidemiological overview of childhood cancer in SA, which could be extrapolated to other regional Arab populations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27684","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T06:12:45Z","timestamp":1551161565000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Incidence, clinical distribution, and patient characteristics of childhood cancer in Saudi Arabia: A population\u2010based analysis"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0135-7509","authenticated-orcid":false,"given":"Asim F.","family":"Belgaumi","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology King Faisal Specialist Hospital and Research Center and the King Fahad National Center for Children's Cancer  Riyadh Saudi Arabia"},{"name":"Department of Oncology Aga Khan University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghulam Q.","family":"Pathan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology King Faisal Specialist Hospital and Research Center and the King Fahad National Center for Children's Cancer  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khawar","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology King Faisal Specialist Hospital and Research Center and the King Fahad National Center for Children's Cancer  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afshan A.","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology King Faisal Specialist Hospital and Research Center and the King Fahad National Center for Children's Cancer  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Al\u2010Fawaz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology King Faisal Specialist Hospital and Research Center and the King Fahad National Center for Children's Cancer  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suleimman","family":"Al\u2010Sweedan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology King Faisal Specialist Hospital and Research Center and the King Fahad National Center for Children's Cancer  Riyadh Saudi Arabia"},{"name":"Jordan University of Science and Technology  Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5740-1302","authenticated-orcid":false,"given":"Mouhab","family":"Ayas","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology King Faisal Specialist Hospital and Research Center and the King Fahad National Center for Children's Cancer  Riyadh Saudi Arabia"},{"name":"Al\u2010Faisal University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amani A.","family":"Al\u2010Kofide","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology King Faisal Specialist Hospital and Research Center and the King Fahad National Center for Children's Cancer  Riyadh Saudi Arabia"},{"name":"Al\u2010Faisal University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21254"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70008-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e32833876c0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2964"},{"issue":"35","key":"e_1_2_9_6_1","first-page":"502","article-title":"The Swiss Childhood Cancer Registry: rationale, organisation and results for the years 2001\u20132005","volume":"137","author":"Michel G","year":"2007","journal-title":"Swiss Med Wkly"},{"issue":"3","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"iii103","DOI":"10.1093\/annonc\/mdq092","article-title":"Childhood cancer incidence and survival in Spain","volume":"21","author":"Peris\u2010Bonet R","year":"2010","journal-title":"Ann Oncol"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.06.006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyq169"},{"key":"e_1_2_9_10_1","unstructured":"Steliarova\u2010FoucherE FrazierAL.World Cancer Report 2014.150 cours Albert Thomas 69372 Lyon Cedex 08 France: International Agency for Research on Cancer; 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