{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:09:50Z","timestamp":1790140190985,"version":"4.0.1"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T00:00:00Z","timestamp":1552435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We sought to evaluate the impact of adjuvant radiotherapy dose on overall survival (OS) after surgical resection for localized intracranial ependymoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>The National Cancer Database (NCDB) was queried from 2004 to 2015 for patients of all ages with intracranial WHO grade II to III ependymoma treated with surgery and 4500 to 7000 cGy of adjuvant radiotherapy. Pearson \u03c7<jats:sup>2<\/jats:sup> test and multivariate logistic regression analyses were used to assess clinicodemographic factors and patterns of care. After propensity\u2010score matching, OS was assessed with Kaplan\u2013Meier analyses and doubly robust estimation with multivariate Cox proportional hazards modeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1153 patients meeting criteria, 529 (46%) received \u2264 5400 cGy and 624 (54%) received\u00a0&gt;\u00a05400 cGy. At a median follow\u2010up of 54.5 months, an OS benefit was observed for\u00a0&gt;\u00a05400 cGy in pediatric patients aged 2\u201318 years (hazard ratio [HR] 0.53; 95% confidence interval [CI] 0.28\u20130.99, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.047). No OS difference was found between \u2264 5400 cGy and\u00a0&gt;\u00a05400 cGy in pediatric patients aged\u00a0&lt;\u00a02 years (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.819) or in adults (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.180). Increasing age, WHO grade III, subtotal resection, and receipt of chemotherapy portended worse OS. Age 2 to 18 years, WHO III grade, supratentorial location, and receipt of chemotherapy were associated with receiving\u00a0&gt;\u00a05400 cGy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adjuvant radiotherapy dose\u00a0&gt;\u00a05400 cGy was associated with improved OS for children aged 2\u201318 years with WHO grade II\u2010III intracranial ependymoma. No OS benefit was found with\u00a0&gt;\u00a05400 cGy in adults or children less than two years of age.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27697","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T15:19:38Z","timestamp":1552490378000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The value of high\u2010dose radiotherapy in intracranial ependymoma"],"prefix":"10.1002","volume":"66","author":[{"given":"Bryan J.","family":"Ager","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Huntsman Cancer Institute University of Utah  Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Christensen","sequence":"additional","affiliation":[{"name":"University of Utah School of Medicine  Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay 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