{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:22:35Z","timestamp":1754396555463,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University of Ottawa Faculty of Medicine Summer Studentship Program"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In the pediatric population, pathologic bleeding is often challenging to identify. The pediatric bleeding questionnaire (PBQ) was developed as a screening tool for von Willebrand disease (VWD) but was designed to be self\u2010completed by children above 12\u00a0years of age. The study objective was to determine whether a modified Self\u2010PBQ could be completed by 8\u2010 to 12\u2010year\u2010old children with adult assistance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>The initial phase involved seven children who underwent cognitive debriefing to identify problems in the questionnaire, resulting in modifications to wording and response options. In phase 2, children completed the modified Self\u2010PBQ independently or with assistance from their parent at five Canadian treatment centers. Parents filled out the Self\u2010PBQ separately to serve as a comparison. Bleeding scores derived from the child self\u2010report were compared to those of the parent proxy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010nine out of 31 patient\/parent pairs successfully completed the Self\u2010PBQ. Child and parent scores demonstrated a high level of agreement with an intraclass correlation (ICC) of 0.825. In the age subgroup analysis, the ICC was 0.834 and 0.824 for the 8\u2010 to 9\u2010year\u2010old and 10\u2010 to 12\u2010year\u2010old groups, respectively. The ICC was also determined in children with type 1 VWD (ICC\u00a0=\u00a00.829) versus those with more severe bleeding disorders (ICC\u00a0=\u00a00.802). Thus, age and disease severity had no significant effect on degree of agreement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study shows that agreement was maintained even in younger children aged 8\u20139\u00a0years and in children with varying bleeding phenotypes. This supports the administration of the modified Self\u2010PBQ to 8\u2010 to 12\u2010year\u2010old children.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27709","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T12:20:43Z","timestamp":1553257243000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Validation of the school age self\u2010administered pediatric bleeding questionnaire (Self\u2010PBQ) in children aged 8\u201312\u00a0years"],"prefix":"10.1002","volume":"66","author":[{"given":"Jessica","family":"Bui","sequence":"first","affiliation":[{"name":"Department of Medicine University of Ottawa  Ottawa Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Martyres","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula D.","family":"James","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen's University  Kingston Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Grabell","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen's University  Kingston Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology British Columbia Children's Hospital  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MacGregor","family":"Steele","sequence":"additional","affiliation":[{"name":"Section of Pediatric Hematology Alberta Children's Hospital  Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Silva","sequence":"additional","affiliation":[{"name":"Kingston General Hospital  Kingston Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret L.","family":"Rand","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology and Translational Medicine The Hospital for Sick Children University of Toronto  Toronto Canada"},{"name":"Departments of Laboratory Medicine &amp; Pathobiology Biochemistry, and Pediatrics University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor S.","family":"Blanchette","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Pediatrics Hospital for Sick Children University of Toronto  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Barrowman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Ottawa  Ottawa Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6913-2808","authenticated-orcid":false,"given":"Robert J.","family":"Klaassen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology\/Oncology Children's Hospital of Eastern Ontario  Ottawa Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1647491"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03499.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03975.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04923.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12747"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26588"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1367\/1539-4409(2003)003<0329:TPAAPP>2.0.CO;2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-5-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023279029852"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12503"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2006.03.012"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6040045"},{"key":"e_1_2_8_15_1","unstructured":"Diagnostic Criteria For Inherited Platelet Function Disorders For The Canadian Rare Inherited Bleeding Disorders Registry (RIBDR).Toronto: Inherited Bleeding Disorders Subcommittee of the Association of Hemophilia Clinic Directors of Canada.2013.https:\/\/www.ahcdc.ca\/storage\/files\/diagnostic-criteria-2013.pdf."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04775.x"}],"container-title":["Pediatric Blood &amp; 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