{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:33:47Z","timestamp":1792416827501,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Elevated tricuspid valve regurgitation jet velocity (TRV \u2265 2.5\u00a0m\/s) is associated with mortality among adults with sickle cell disease (SCD), but correlative biomarkers are not studied according to treatment exposure or genotypes. To investigate the associations between biomarkers and TRV elevation, we examined the relationship between TRV and hemolytic, inflammatory, and cardiac biomarkers, stratified by disease\u2010modifying treatments and SCD genotype. In total, 294 participants with SCD (mean age, 11.0 \u00b1 3.7 years) and 49 hereditary spherocytosis (HS; mean age, 22.9 \u00b1 19.75 years) were included for comparison and enrolled. TRV was elevated in 30.7% of children with SCD overall: 18.8% in HbSC\/HbS\u03b2\n                    <jats:sup>+<\/jats:sup>\n                    \u2010thalassemia, 28.9% in untreated HbSS\/HbS\u03b2\n                    <jats:sup>0<\/jats:sup>\n                    \u2010thalassemia, 34.2% in HbSS\/HbS\u03b2\n                    <jats:sup>0<\/jats:sup>\n                    \u2010thalassemia hydroxyurea\u2010treated, and 57% in HbSS\/HbS\u03b2\n                    <jats:sup>0<\/jats:sup>\n                    \u2010thalassemia chronic transfusion treated. TRV was elevated in 10.7% and 27.8% in HS children and adults, respectively. In children with SCD, elevated TRV was correlated with hemoglobin (odds ratio [OR]\u00a0= 0.78,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.004), lactate dehydrogenase (LDH; OR\u00a0=\u00a02.52,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.005), and N\u2010terminal pro\u2010brain natriuretic peptide (NT\u2010pro BNP; OR\u00a0=\u00a01.003,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.004). In multivariable logistic regression, adjusting for genotype, sex, hemolytic index, and treatment, hemoglobin concentration remained the only significant variable associated with elevated TRV in untreated HbSS\/HbS\u03b2\n                    <jats:sup>0<\/jats:sup>\n                    \u2010thalassemia participants. TRV was not associated with inflammatory markers, other markers of hemolysis, or NT\u2010pro BNP in untreated HbSS\/HbS\u03b2\n                    <jats:sup>0<\/jats:sup>\n                    \u2010thalassemia. Neither hemoglobin nor LDH was associated with TRV in HbSC\/HbS\u03b2\n                    <jats:sup>+<\/jats:sup>\n                    \u2010thalassemia. These results suggest that elevated TRV is influenced by the degree of anemia, possibly reflecting sickling as part of the disease pathophysiology. Prospective studies should monitor hemoglobin concentration as children with SCD age into adulthood, prompting initiation of TRV screening and monitoring.\n                  <\/jats:p>","DOI":"10.1002\/pbc.27717","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T08:01:29Z","timestamp":1553500889000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Elevated tricuspid regurgitation velocity in congenital hemolytic anemias: Prevalence and laboratory correlates"],"prefix":"10.1002","volume":"66","author":[{"given":"Amber M.","family":"Yates","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology Oncology Texas Children's Hospital  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya M.","family":"Joshi","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Le Bonheur Children's Hospital  Memphis 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Hospital  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jola","family":"Dowdy","sequence":"additional","affiliation":[{"name":"Department of Hematology St. Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Cotton","sequence":"additional","affiliation":[{"name":"Department of Hematology St. Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolian","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell E.","family":"Ware","sequence":"additional","affiliation":[{"name":"Division of Hematology Cincinnati Children's Hospital Medical Center  Cincinnati 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