{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:34:07Z","timestamp":1790393647408,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T00:00:00Z","timestamp":1555891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006058","name":"St. Baldrick's Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006058","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Large B\u2010cell lymphoma with <jats:italic>IRF4<\/jats:italic> rearrangement is a provisional entity in the 2017 World Health Organization classification. In order to characterize these lymphomas in children from the United States, <jats:italic>IRF4<\/jats:italic> FISH and immunohistochemical stains were performed on 32 follicular lymphoma and diffuse large B\u2010cell lymphoma (DLBCL) from Children's Oncology Group studies. Two DLBCLs (6%) had <jats:italic>IRF4<\/jats:italic> rearrangements, one involving the ileocecal valve and another involving the tonsil and cerebrospinal fluid. Both cases had strong, diffuse IRF4\/MUM1 immunohistochemical staining, which may be a pathologic clue to the diagnosis. Reclassification of these cases may have prognostic and therapeutic implications.<\/jats:p>","DOI":"10.1002\/pbc.27770","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T05:34:19Z","timestamp":1555997659000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["<i>IRF4<\/i> translocation status in pediatric follicular and diffuse large B\u2010cell lymphoma patients enrolled in Children's Oncology Group trials"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1898-1252","authenticated-orcid":false,"given":"Karen M.","family":"Chisholm","sequence":"first","affiliation":[{"name":"Department of Laboratories Seattle Children's Hospital  Seattle Washington"},{"name":"Department of Laboratory Medicine University of Washington  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Mohlman","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Utah  Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Liew","sequence":"additional","affiliation":[{"name":"ARUP Institute for Clinical and Experimental Pathology  Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4072-5546","authenticated-orcid":false,"given":"Amanda","family":"Termuhlen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Minnesota Medical School  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2075-434X","authenticated-orcid":false,"given":"Mitchell S.","family":"Cairo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Medicine, Pathology Microbiology and Immunology and Cell Biology and Anatomy New York Medical College  Valhalla New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Gross","sequence":"additional","affiliation":[{"name":"National Cancer Institute  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherrie L.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Utah  Salt Lake City Utah"},{"name":"ARUP Institute for Clinical and Experimental Pathology  Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney R.","family":"Miles","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Utah  Salt Lake City Utah"},{"name":"ARUP Institute for Clinical and Experimental Pathology  Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.6.1959"},{"key":"e_1_2_8_3_1","first-page":"278","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Jaffe ES","year":"2017"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31826b9b57"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.013177"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-330795"},{"key":"e_1_2_8_7_1","first-page":"280","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Pittaluga S","year":"2017"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25881"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.3369"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1545"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26236"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-015-1855-z"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318166f46a"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/IJPM.IJPM_194_17"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.27770","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pbc.27770","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.27770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T23:01:51Z","timestamp":1694386911000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.27770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,22]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/pbc.27770"],"URL":"https:\/\/doi.org\/10.1002\/pbc.27770","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,22]]},"assertion":[{"value":"2019-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e27770"}}