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We report a case of a 17\u2010year\u2010old female with Hodgkin lymphoma who developed severe chemotherapy\u2010related toxicities. She was subsequently found to have peripheral blood lymphocyte TL\u00a0&lt;\u00a01st percentile and a pathogenic variant in <jats:italic>TERT<\/jats:italic> inherited from her father. This case demonstrates that early genetic evaluation of patients who experience greater than expected therapy\u2010related toxicities may be warranted to help guide further decisions regarding therapy, imaging modalities, and lifelong cancer prevention surveillance.<\/jats:p>","DOI":"10.1002\/pbc.27779","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T05:15:42Z","timestamp":1556860542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Severe therapy\u2010related toxicities after treatment for Hodgkin lymphoma due to a pathogenic <i>TERT<\/i> variant and shortened telomeres"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8932-863X","authenticated-orcid":false,"given":"Jennifer E.","family":"Agrusa","sequence":"first","affiliation":[{"name":"Department of Pediatrics Dan L. 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Duncan Cancer Center Baylor College of Medicine  Houston Texas"},{"name":"Texas Children's Cancer and Hematology Centers Texas Children's Hospital  Houston Texas"},{"name":"Departments of Pediatrics and Molecular and Human Genetics Baylor College of Medicine  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney D.","family":"DiNardo","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon E.","family":"Plon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dan L. Duncan Cancer Center Baylor College of Medicine  Houston Texas"},{"name":"Texas Children's Cancer and Hematology Centers Texas Children's Hospital  Houston Texas"},{"name":"Departments of Pediatrics and Molecular and Human Genetics Baylor College of Medicine  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1895-8810","authenticated-orcid":false,"given":"Olive S.","family":"Eckstein","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dan L. 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