{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:52Z","timestamp":1786978432518,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH\/NCI","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Proton therapy is currently used in the management of pediatric tumors to decrease late toxicities. However, one of the criticisms of proton therapy is the limited data regarding efficacy on disease control. The purpose of this study was to examine local and distant control rates after proton therapy for neuroblastoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and materials<\/jats:title>\n                    <jats:p>\n                      Eighteen patients with high\u2010risk (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a016) and locally recurrent neuroblastoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02) were treated with curative intent and received proton therapy to the primary site and up to three post\u2010induction MIBG\u2010avid metastatic sites. Primary sites (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a018) were treated to 21\u201336\u00a0Gy (relative biological effectiveness [RBE]), and metastatic sites (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a016) were treated to 21\u201324\u00a0Gy (RBE). Local control and survival rates were calculated using the Kaplan\u2013Meier method.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>With a median follow\u2010up of 60.2 months, two\u2010 and five\u2010year local control rates at the irradiated primary site were 94% and 87%, respectively. No failures at irradiated distant metastatic sites were observed. The five\u2010year progression\u2010free survival (PFS) was 64%, and the five\u2010year overall survival (OS) was 94%. The extent of surgical resection was not associated with local control, PFS, or OS. No radiation\u2010related nephropathy or hepatopathy was reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Excellent local control was achieved using proton therapy to the primary and post\u2010induction MIBG\u2010positive distant sites. The predominant site of failure is progression in post\u2010induction non\u2010MIBG\u2010avid distant sites. Although proton therapy provides high rates of local control with acceptable toxicity for neuroblastoma, further advances in systemic therapy are needed for the improved control of systemic disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.27786","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T01:15:57Z","timestamp":1556846157000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Efficacy of proton therapy in children with high\u2010risk and locally recurrent neuroblastoma"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0716-2569","authenticated-orcid":false,"given":"Alexander F.","family":"Bagley","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Grosshans","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy V.","family":"Philip","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2126-9768","authenticated-orcid":false,"given":"Jennifer","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Texas Children's Hospital  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Frances","family":"McAleer","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"McGovern","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Lassen\u2010Ramshad","sequence":"additional","affiliation":[{"name":"Danish Centre for Particle Therapy Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0269-3045","authenticated-orcid":false,"given":"Arnold C.","family":"Paulino","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.11.043"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.05.020"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.07.019"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24350"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.07.719"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)02713-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00165"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.08.035"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24606"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-8-142"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.10.047"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.04.004"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.2642"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3493-0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","unstructured":"CaseyDL KushnerBH CheungNV ModakS LaQuagliaMP WoldenSL.Dose\u2010escalation is needed for gross disease in high\u2010risk neuroblastoma.2018;65(7):e27009.","DOI":"10.1002\/pbc.27009"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000264"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.04.003"}],"container-title":["Pediatric Blood &amp; 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