{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:04:22Z","timestamp":1753869862402,"version":"3.41.2"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lymphoid malignancies other than acute lymphoblastic leukemia (ALL) are rare in children with Down syndrome (DS). Information about the toxicity of chemotherapy and prognosis is largely derived from the experience of children with DS and ALL or children without DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We describe the treatment and outcome of two unusual lymphoid malignancies in children with DS. One patient was diagnosed with Burkitt lymphoma (BL) and the second, after treatment for B precursor ALL, with T\u2010cell EBV\u2010positive proliferative disorder (LPD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BL was treated with standard doses of LMB group B therapy subsequently intensified to group C therapy, including high\u2010dose methotrexate (HD\u2010MTX, 3\u20138\u00a0g\/m<jats:sup>2<\/jats:sup>). The patient did not experience excessive toxicity and remains in complete remission 13 months later. Despite presentation with disseminated disease the patient with T\u2010cell EBV\u2010positive LPD after treatment for B precursor ALL responded to dexamethasone and rituximab and remains in complete remission two years later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Upfront reduction of the high treatment intensity, which is associated with excellent survival outcomes in BL, may not be warranted in all children with DS. Response to therapy and prognosis of T\u2010cell EBV\u2010positive LPD in a patient with DS was not predicted by reported experience in the absence of DS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27822","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T12:31:14Z","timestamp":1559046674000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unusual lymphoid malignancy and treatment response in two children with Down syndrome"],"prefix":"10.1002","volume":"66","author":[{"given":"Ashley","family":"Geerlinks","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology The Hospital for Sick Children Department of Paediatrics University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Keis","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology The Hospital for Sick Children Department of Paediatrics University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Ngan","sequence":"additional","affiliation":[{"name":"Division of Pathology Department of Paediatric Laboratory Medicine The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amer","family":"Shammas","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Vali","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1158-186X","authenticated-orcid":false,"given":"Johann","family":"Hitzler","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology The Hospital for Sick Children Department of Paediatrics University of Toronto  Toronto Ontario Canada"},{"name":"Developmental and Stem Cell Biology The Hospital for Sick Children Research Institute  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,28]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"OMIM[database online].http:\/\/wwwncbinlmnihgov#190685. 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