{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T17:40:57Z","timestamp":1765993257791,"version":"3.41.2"},"reference-count":7,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neonatal neuroblastoma may require chemotherapy either due to mass effect or unfavourable cytogenetics. This case focuses on using pharmacokinetic (PK) guided chemotherapy to treat neonatal neuroblastoma. A newborn baby was noted to have left leg immobility. Imaging showed a retroperitoneal tumour with spinal canal extension causing spinal cord compression. PK\u2010guided carboplatin was given after conventionally dosed chemotherapy demonstrated no improvement. After initiation of PK therapy, clinical and radiological improvement was seen. We discuss our decision to use PK\u2010guided chemotherapy despite guidelines recommending weight\u2010based dosing and discuss the benefits in terms of clinical efficacy without increased toxicity.<\/jats:p>","DOI":"10.1002\/pbc.27825","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T12:29:50Z","timestamp":1559046590000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The use of pharmacokinetically guided carboplatin chemotherapy in a pre\u2010term infant with neuroblastoma\u2010associated spinal cord compression"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7083-4989","authenticated-orcid":false,"given":"Jessica","family":"Hawley","sequence":"first","affiliation":[{"name":"Great North Children's Hospital Newcastle Upon Tyne Hospitals NHS Trust  Newcastle\u2010Upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gareth J.","family":"Veal","sequence":"additional","affiliation":[{"name":"Northern Institute for Cancer Research Newcastle University  Newcastle\u2010Upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Errington","sequence":"additional","affiliation":[{"name":"Northern Institute for Cancer Research Newcastle University  Newcastle\u2010Upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leigh G.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Great North Children's Hospital Newcastle Upon Tyne Hospitals NHS Trust  Newcastle\u2010Upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah A.","family":"Tweddle","sequence":"additional","affiliation":[{"name":"Great North Children's Hospital Newcastle Upon Tyne Hospitals NHS Trust  Newcastle\u2010Upon\u2010Tyne UK"},{"name":"Wolfson Childhood Cancer Research Centre Northern Institute for Cancer Research Newcastle University  Newcastle\u2010Upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2012.05.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-017-2761-2"},{"key":"e_1_2_6_4_1","unstructured":"Children's Cancer and Leukaemia group (CCLG).Treatment of patients with low\/intermediate risk neuroblastoma.2015.https:\/\/www.cclg.org.uk\/write\/MediaUploads\/Member%20area\/Treatment%20guidelines\/CCLG_Low-Inter_Risk_Neuroblastoma_guidelines_FINAL_March_2015(1).pdf. Accessed June 6 2018."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.07.011"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-016-2975-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-018-3625-5"},{"key":"e_1_2_6_8_1","unstructured":"Children's Cancer and Leukaemia Group (CCLG).CCLG guidelines for the management of neonates (under 3 months) with intracocular retinoblastoma using carboplatin therapeutic monitoring.2018.https:\/\/www.cclg.org.uk\/write\/MediaUploads\/Member%20area\/Treatment%20guidelines\/CCLG_Neonatal_RB_carboplatin_Dosing_Guidelines_FINAL_v2_20-12-2017.pdf. Accessed September 12 2018."}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.27825","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pbc.27825","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.27825","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T03:08:18Z","timestamp":1694315298000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.27825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,28]]},"references-count":7,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/pbc.27825"],"URL":"https:\/\/doi.org\/10.1002\/pbc.27825","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"type":"print","value":"1545-5009"},{"type":"electronic","value":"1545-5017"}],"subject":[],"published":{"date-parts":[[2019,5,28]]},"assertion":[{"value":"2019-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e27825"}}