{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:52Z","timestamp":1786978432443,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There are very few studies about the role of repeat irradiation (RT2) for children with recurrent supratentorial high\u2010grade glioma (HGG). It was the aim of this study to assess the effectiveness and safety of RT2 in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>This was a retrospective cohort study of 40 children age 18\u00a0years and under with recurrent supratentorial HGG who had received at least one course of RT. In\u2010field reirradiation volumes included focal or whole brain RT, with doses ranging from 30 to 54\u00a0Gy. The primary endpoint was overall survival (OS) from the first day of RT2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fourteen patients underwent RT2. The median survival of these patients was 6.5\u00a0months. Patients with \u226512\u00a0months elapsed time between RT1 and RT2 experienced longer OS than patients who had\u00a0&lt;\u00a012\u00a0months (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.009). There was no difference in OS between patients with or without germline mutations (e.g., Lynch, Li\u2013Fraumeni, or constitutional mismatch\u2010repair deficiency,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.20). Ten patients received RT2 that overlapped with RT1 volumes for locally recurrent disease. Of this group, 80% experienced clinical benefit from in\u2010field RT2, defined as clinical\/radiologic response or stable disease. Ninety\u2010three percent completed the prescribed course of RT2, with one patient developing grade 3 radiation necrosis four months after RT2. When compared with 26 patients who were not offered reirradiation, those selected for RT2 had improved median survival from the time of first disease progression (9.4\u00a0vs 3.8\u00a0months,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Reirradiation for children with recurrent supratentorial HGG is a safe, effective treatment that provides short\u2010term disease control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.27881","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T12:05:42Z","timestamp":1560773142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Repeat irradiation for children with supratentorial high\u2010grade glioma"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9762-6901","authenticated-orcid":false,"given":"Derek S.","family":"Tsang","sequence":"first","affiliation":[{"name":"Radiation Medicine Program Princess Margaret Cancer Centre University Health Network  Toronto Ontario Canada"},{"name":"Division of Haematology\/Oncology Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology Queen's University  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6832-6539","authenticated-orcid":false,"given":"Eric","family":"Bouffet","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology Hospital for Sick Children  Toronto Ontario 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