{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:53:57Z","timestamp":1789012437606,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Juvenile myelomonocytic leukemia (JMML) has a poor prognosis in general, with hematopoietic stem cell transplant (HSCT) remaining the standard of care for cure. The hypomethylating agent, azacitidine, has been used as a bridging therapy to transplant. However, no patients have been treated with azacitidine without an HSCT post azacitidine. We report on an infant with JMML with somatic <jats:italic>KRAS<\/jats:italic> G12A mutation and monosomy 7 who achieved sustained remission following azacitidine monotherapy. He also developed an aberrant B\u2010lymphoblast population which declined with similar kinetics as his JMML\u2010associated abnormalities, suggesting that a B\u2010lymphoblast population in JMML does not always progress to acute leukemia.<\/jats:p>","DOI":"10.1002\/pbc.27905","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T09:05:43Z","timestamp":1561712743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Sustained remission with azacitidine monotherapy and an aberrant precursor B\u2010lymphoblast population in juvenile myelomonocytic leukemia"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0470-1846","authenticated-orcid":false,"given":"Saman K.","family":"Hashmi","sequence":"first","affiliation":[{"name":"Department of Pediatrics Section of Hematology Oncology Texas Children's Hospital\/Baylor College of Medicine  Houston 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