{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:28:06Z","timestamp":1790692086675,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Preexisting endothelial dysfunction and vascular injury sustained during allogeneic hematopoietic cell transplantation (HCT) increases risk for endothelial injury\u2010related complications such as posterior reversible encephalopathy syndrome (PRES) and transplant\u2010associated thrombotic microangiopathy (TA\u2010TMA) in patients with sickle cell disease (SCD). We report two patients with SCD who developed PRES following allogeneic HCT. In both patients, PRES\u2010related symptoms resolved only after a diagnosis of TA\u2010TMA was established and eculizumab therapy was initiated. Renal manifestations at diagnosis included non\u2010nephrotic range proteinuria and hypertension. This report highlights the importance of screening PRES\u2010affected SCD HCT recipients for TA\u2010TMA as usual treatment strategies may be inadequate.<\/jats:p>","DOI":"10.1002\/pbc.27912","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T11:59:51Z","timestamp":1562068791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Successful treatment with eculizumab for posterior reversible encephalopathy syndrome due to underlying transplant\u2010associated thrombotic microangiopathy in patients transplanted for sickle cell disease"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6068-5783","authenticated-orcid":false,"given":"Nabanita","family":"Bhunia","sequence":"first","affiliation":[{"name":"Division of Hematology, Oncology, Blood and Bone Marrow Transplant Nationwide Children's Hospital  Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9768-7520","authenticated-orcid":false,"given":"Rolla","family":"Abu\u2010Arja","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, Blood and Bone Marrow Transplant Nationwide Children's Hospital  Columbus Ohio"},{"name":"Department of Pediatrics The Ohio State University College of Medicine  Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4498-0322","authenticated-orcid":false,"given":"Rajinder P.S.","family":"Bajwa","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, Blood and Bone Marrow Transplant Nationwide Children's Hospital  Columbus Ohio"},{"name":"Department of Pediatrics The Ohio State University College of Medicine  Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery J.","family":"Auletta","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, Blood and Bone Marrow Transplant Nationwide Children's Hospital  Columbus Ohio"},{"name":"Department of Pediatrics The Ohio State University College of Medicine  Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3371-2920","authenticated-orcid":false,"given":"Hemalatha G.","family":"Rangarajan","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, Blood and Bone Marrow Transplant Nationwide Children's Hospital  Columbus Ohio"},{"name":"Department of Pediatrics The Ohio State University College of Medicine  Columbus 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