{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:26:29Z","timestamp":1784719589222,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Beryl Thyer Memorial Africa Trust"},{"name":"World Child Cancer"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Burkitt lymphoma (BL) is a curable childhood cancer. Treatment adherence is crucial for a good outcome, but is potentially problematic in low\u2010 and middle\u2010income countries owing to parental financial constraints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the association of destitution with treatment adherence and its effect on the survival of patients with BL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients received free medical treatment from a twinning programme at two Cameroon Baptist hospitals. A destitution assessment questionnaire, based on socioeconomic status, was completed at diagnosis. Medical records were reviewed for treatment adherence and survival. Chi\u2010squared and Fisher's exact tests were used to compare groups. Kaplan\u2010Meier plots were used to calculate overall survival, and log\u2010rank chi\u2010squared tests when comparing survival rates between patient subgroups. Significance was measured at <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 225 children with BL had a mean age of 8.2\u00a0years (median 8.0) and the overall survival was 52%. The mean family destitution score was 56% on a linear scale. Few (8%) patients delayed treatment appointments. A quarter (25%) experienced more than a 1\u2010week follow\u2010up delay and 9.8% absconded within 1 year. The destitution score was not significantly associated with delay of treatment, but with delay in follow\u2010up (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Guardian relationship (single mother) and patient's age were significantly associated with overall survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.025).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Though linked to poor follow\u2010up, destitution was not significantly associated with absconding patients, poor outcome or poor adherence to treatment, probably due to comprehensive financial support from the international twinning programme. However, additional support for single mothers should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27946","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T12:16:09Z","timestamp":1566476169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Destitution, treatment adherence and survival of children with Burkitt lymphoma in a twinning programme in Northwest Cameroon"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5512-9624","authenticated-orcid":false,"given":"Glenn M.","family":"Afungchwi","sequence":"first","affiliation":[{"name":"Department of Paediatrics Mbingo Baptist Hospital  Banso Cameroon"},{"name":"Department of Paediatrics and Child Health Faculty of Medicine and Health Sciences Stellenbosch University and Tygerberg Hospital  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hesseling","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health Faculty of Medicine and Health Sciences Stellenbosch University and Tygerberg Hospital  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine L.","family":"van Elsland","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health Faculty of Medicine and Health Sciences Stellenbosch University and Tygerberg Hospital  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Kouya","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Mbingo Baptist Hospital  Banso Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6838-0180","authenticated-orcid":false,"given":"Mariana","family":"Kruger","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health Faculty of Medicine and Health Sciences Stellenbosch University and Tygerberg Hospital  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,22]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.11.3370"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24407"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.09013.x"},{"key":"e_1_2_13_5_1","first-page":"166","article-title":"Burkitt's lymphoma in Africa, a review of the epidemiology and etiology","volume":"7","author":"Orem J","year":"2007","journal-title":"Afr Health Sci"},{"key":"e_1_2_13_6_1","unstructured":"Central Intelligence Agency.The world factbook \u2013 Central Intelligence Agency.2018.https:\/\/www.cia.gov\/library\/publications\/the-world-factbook\/geos\/cm.html. 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