{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:31:19Z","timestamp":1764174679493,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Secondary hemophagocytic syndrome (HPS) has been described after autologous hematopoietic cell transplant (AutoHCT). We report two cases of secondary HPS after novel consolidation therapy for high\u2010risk neuroblastoma as part of an institutional phase 2 trial incorporating immunotherapy into a \u201cstandard\u201d AutoHCT regimen. Both patients developed liver dysfunction beyond expected course of hepatic veno\u2010occlusive disease, coagulopathy, hyperferritinemia, and when evaluated, elevated soluble interleukin\u20102 receptor and hemophagocytosis. These cases highlight the need for clinicians to have a high index of suspicion for immune\u2010related complications in patients receiving immune therapies.<\/jats:p>","DOI":"10.1002\/pbc.27964","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T06:50:09Z","timestamp":1565679009000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Secondary hemophagocytic syndrome after autologous hematopoietic cell transplant and immune therapy for neuroblastoma"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8998-0732","authenticated-orcid":false,"given":"Rebecca","family":"Epperly","sequence":"first","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne","family":"Furman","sequence":"additional","affiliation":[{"name":"Department of 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