{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T17:51:50Z","timestamp":1785606710326,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Undernutrition impacts clinical outcome adversely in children with cancer. This study aimed to validate a nutritional algorithm with specific application to the low\u2010 and middle\u2010income country (LMIC) setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Fifty children with a new diagnosis of cancer were enrolled in this randomized interventional study. Weight, height\/length, and mid\u2010upper\u2010arm circumference (MUAC) were measured at baseline. The study arm was administered nutritional care as per the algorithm and the control arm received the institutional standard of care. Weight was monitored regularly and MUAC was repeated after 3 months. Children were classified based on weight for height if &lt;2 years of age or body mass index if \u22652 years, as normal, wasted, and severely wasted. The algorithmic approach comprised administration of oral supplements, nasogastric feeds, and\/or parenteral nutrition based on objective assessment of the nutritional status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty patients were analyzed (study: 25, control: 25). Four in the study arm (16%) and six in the control arm (24%) had wasting at baseline. MUAC was &lt;5th percentile in 15 (60%) and 13 (52%) patients in the study and control arms, respectively. At the end of 3 months, the median increment in weight was 0.8\u00a0kg (interquartile range [IQR]: \u20130.02; 2.00) and 0.0\u00a0kg (IQR: \u20130.70; 1.25) in the study and control arms, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.153). The median increment in MUAC was 1.20\u00a0cm (IQR: 0.10; 2.30) and 0.00\u00a0cm (IQR: \u20130.50; 1.10) in the study and control arms, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.020).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The application of an algorithm designed for use in LMICs resulted in significant improvement in nutritional status, as measured by MUAC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27980","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T05:53:21Z","timestamp":1567058001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Validation of an algorithmic nutritional approach in children undergoing chemotherapy for cancer"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0076-994X","authenticated-orcid":false,"given":"Sidharth","family":"Totadri","sequence":"first","affiliation":[{"name":"Pediatric Hematology\u2010Oncology unit Department of Pediatrics Advanced Pediatrics Center Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9071-7651","authenticated-orcid":false,"given":"Amita","family":"Trehan","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\u2010Oncology unit Department of Pediatrics Advanced Pediatrics Center Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diviyaa","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\u2010Oncology unit Department of Pediatrics Advanced Pediatrics Center Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Viani","sequence":"additional","affiliation":[{"name":"ITACI\u2014Hematology\u2010Oncology Department of Instituto da Crian\u00e7a do Hospital das Cl\u00ednicas School of Medicine, University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5711-7440","authenticated-orcid":false,"given":"Ronald","family":"Barr","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Pathology and Medicine McMaster Children's Hospital  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5077-5582","authenticated-orcid":false,"given":"Elena J.","family":"Ladas","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology\/Stem Cell Transplant Columbia University Medical Center  New York City New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"PDQ Cancer Information Summaries","author":"PDQ Supportive and Palliative Care Editorial Board","year":"2002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26590"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2674-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26281"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.06.006"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.52.6962"},{"key":"e_1_2_8_8_1","unstructured":"National Family Health Survey.Key findings from NFHS\u20104.http:\/\/rchiips.org\/NFHS\/factsheet_NFHS-4.shtml. Accessed September 16 2016."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26016"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509X.175834"},{"key":"e_1_2_8_11_1","unstructured":"WHO.The WHO child growth standards.http:\/\/www.who.int\/childgrowth\/standards\/en\/. Accessed December 12 2018."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/34.11.2540"},{"key":"e_1_2_8_13_1","unstructured":"National Institute of Nutrition.Dietary guidelines for Indians\u2014a manual.http:\/\/ninindia.org\/DietaryGuidelinesforNINwebsite.pdf. Accessed December 12 2018"},{"key":"e_1_2_8_14_1","unstructured":"WHO.Human energy requirements. Report of a joint FAO\/WHO\/UNU expert consultation Rome Italy 17\u201024 October 2001.https:\/\/www.who.int\/nutrition\/publications\/nutrientrequirements\/9251052123\/en\/. Accessed December 12 2018."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuu062"},{"key":"e_1_2_8_16_1","article-title":"Unmet needs in nutritional care in African paediatric oncology units","author":"Schoeman J","year":"2018","journal-title":"J Trop Pediatr"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20435"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.110.000141"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20371"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3182002a65"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509X.175832"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.27980","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pbc.27980","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.27980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T19:36:49Z","timestamp":1694201809000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.27980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,28]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1002\/pbc.27980"],"URL":"https:\/\/doi.org\/10.1002\/pbc.27980","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,28]]},"assertion":[{"value":"2019-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e27980"}}