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Rather than omit asparaginase from the treatment of acute lymphoblastic leukemia or lymphoblastic lymphoma patients with hypersensitivity to pegaspargase, we continued pegaspargase treatments for nine pediatric patients, utilizing a rapid desensitization protocol. There were no adverse events related to the pegaspargase during desensitization, and all patients who were checked had asparaginase serum levels above the threshold of 0.1 IU\/mL at 7 to 14 days after pegaspargase therapy.<\/jats:p>","DOI":"10.1002\/pbc.28021","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T07:20:42Z","timestamp":1569914442000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Desensitization to pegaspargase in children with acute lymphoblastic leukemia and lymphoblastic lymphoma"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5690-0855","authenticated-orcid":false,"given":"Keith J.","family":"August","sequence":"first","affiliation":[{"name":"Children's Mercy Hospitals  Kansas City Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Farooki","sequence":"additional","affiliation":[{"name":"Children's Mercy Hospitals  Kansas City Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy M.","family":"Fulbright","sequence":"additional","affiliation":[{"name":"Children's Mercy Hospitals  Kansas City Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"August","sequence":"additional","affiliation":[{"name":"Children's Mercy Hospitals  Kansas City Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay M.","family":"Portnoy","sequence":"additional","affiliation":[{"name":"Children's Mercy Hospitals  Kansas City Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Pommert","sequence":"additional","affiliation":[{"name":"Children's Hospital of Wisconsin  Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Burke","sequence":"additional","affiliation":[{"name":"Children's Hospital of Wisconsin  Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M.","family":"Guest","sequence":"additional","affiliation":[{"name":"Children's Mercy Hospitals  Kansas City Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10]]},"reference":[{"issue":"4","key":"e_1_2_7_2_1","first-page":"111","article-title":"L\u2010Asparaginase: discovery and development as a tumor\u2010inhibitory agent","volume":"65","author":"Broome JD","year":"1981","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.5.1211"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.2070"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200404000-00002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.137380"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-027714"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10096"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-367904"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-534347"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181e003c7"},{"issue":"4","key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0091-6749(98)70373-2","article-title":"Rapid desensitization for L\u2010asparaginase hypersensitivity","volume":"101","author":"Bonno M","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.12.908"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62002-8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488606777934413"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-012-1273-x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.08.002"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1397658"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.02439"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401162"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2015.01.011"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25299"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1386305"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27797"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-035006"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-119866"}],"container-title":["Pediatric Blood &amp; 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