{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:43:31Z","timestamp":1787867011177,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","award":["1K12HS026390\u201001"],"award-info":[{"award-number":["1K12HS026390\u201001"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Universal newborn screening and improved treatment options have led to increased survival in sickle cell disease (SCD). However, patients with SCD still rely heavily on acute care services.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the variation seen in hospitalizations for the top complaints for ED visits for children with SCD nationally.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a retrospective review of the Pediatric Health Information Systems (PHIS) Database between October 2011 and September 2015. Emergency department (ED) encounters were selected by using International Classification of Diseases, Ninth Edition, Clinical Modification (ICD\u20109\u2010CM) codes for SCD with and without crisis, fever, and pain. Univariate analyses were performed, as well as index of dispersion (ID) to assess variation by day of the week and region. ANOVA and\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test were used to determine statistical significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 68\u00a0661 ED encounters at 36 hospitals met the criteria for inclusion. Of those encounters, 50.1% were admitted to the hospital. Pain and fever were the most common primary diagnoses among this population. Although variation in hospitalization was seen overall, as well as for a primary diagnosis of pain or fever, this variation was not explained by weekday\/weekend designation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of our study confirm pain and fever as the most common primary diagnoses for children with SCD who seek acute care, as well as demonstrate that while significant variation in hospitalization exists, it is not associated with day of the week. Further studies to elucidate patient\u2010 and hospital\u2010level factors that influence admission variation are necessary.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.28067","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T06:19:46Z","timestamp":1573712386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Variation in hospital admission of sickle cell patients from the emergency department using the Pediatric Health Information System"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2906-6102","authenticated-orcid":false,"given":"Seethal A.","family":"Jacob","sequence":"first","affiliation":[{"name":"Section of Pediatric Hematology Oncology, Department of Pediatrics Indiana University  Indianapolis Indiana"},{"name":"Center for Pediatric and Adolescent Comparative Effectiveness Research Indiana University  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6195-4367","authenticated-orcid":false,"given":"Emily L.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Section of Pediatric Hematology Oncology, Department of Pediatrics Indiana University  Indianapolis Indiana"},{"name":"Center for Pediatric and Adolescent Comparative Effectiveness Research Indiana University  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneli R.","family":"Cochrane","sequence":"additional","affiliation":[{"name":"Section of Pediatric Hematology Oncology, Department of Pediatrics Indiana University  Indianapolis Indiana"},{"name":"Center for Pediatric and Adolescent Comparative Effectiveness Research Indiana University  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron E.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Center for Pediatric and Adolescent Comparative Effectiveness Research Indiana University  Indianapolis Indiana"},{"name":"Department of Pediatrics Children's Health Services Research Indiana University School of Medicine  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"William E.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Center for Pediatric and Adolescent Comparative Effectiveness Research Indiana University  Indianapolis Indiana"},{"name":"Department of Pediatrics Children's Health Services Research Indiana University School of Medicine  Indianapolis Indiana"},{"name":"Section of Pediatric Gastroenterology Hepatology, and Nutrition Department of Pediatrics Indiana University School of Medicine  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21781"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-233700"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21807"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21408"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25024"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24534"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22874"},{"key":"e_1_2_12_9_1","unstructured":"Pediatric Health Information Systems Database (PHIS).Children's Hopsital Association Lenexa KS.https:\/\/www.childrenshospitals.org\/phis."},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.1639"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.17.2048"},{"key":"e_1_2_12_12_1","unstructured":"U.S. Department of Commerce Economics and Statistics Administration U.S. Census Bureau. Prepared by the Geography Division.https:\/\/www2.census.gov\/geo\/pdfs\/maps-data\/maps\/reference\/us_regdiv.pdf."},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2014.12.080"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20180"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.378"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22069"},{"key":"e_1_2_12_17_1","volume-title":"Evidence\u2010Based Management of Sickle Cell Disease: Expert Panel Report","author":"NHLBI","year":"2014"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.3.526"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/acem.12626"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000001569"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.2273"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25432"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.28067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pbc.28067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.28067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T01:28:58Z","timestamp":1693963738000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.28067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,14]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1002\/pbc.28067"],"URL":"https:\/\/doi.org\/10.1002\/pbc.28067","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,14]]},"assertion":[{"value":"2019-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e28067"}}