{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:56:04Z","timestamp":1773057364153,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pediatric histiocytic sarcoma (HS) clonally related to anteceding leukemia is a rare malignancy with poor outcome. We performed a molecular characterization of HS and the corresponding leukemia by methylation arrays and whole\u2010exome sequencing and found a variety of aberrations in both entities with deletions of <jats:italic>CDKN2A\/B<\/jats:italic> as a recurrent finding. Furthermore, data from genome\u2010wide mutation analysis from one patient allowed the reconstruction of a sequence of tumorigenesis of leukemia and HS lesions including the acquisition of a putatively activating KRAS frameshift deletion (p.A66fs). Our results provide an insight into the genetic landscape of pediatric HS clonally related to anteceding leukemia.<\/jats:p>","DOI":"10.1002\/pbc.28074","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T10:20:51Z","timestamp":1574072451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Genome\u2010wide analysis of acute leukemia and clonally related histiocytic sarcoma in a series of three pediatric patients"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0455-8338","authenticated-orcid":false,"given":"Matthias","family":"Bleeke","sequence":"first","affiliation":[{"name":"Division of Pediatric Stem Cell Transplant and Immunology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Johann","sequence":"additional","affiliation":[{"name":"Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ)  Heidelberg Germany"},{"name":"Division of Pediatric Neurooncology German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ)  Heidelberg Germany"},{"name":"Department of Pediatric Hematology and Oncology Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Gr\u00f6bner","sequence":"additional","affiliation":[{"name":"Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ)  Heidelberg Germany"},{"name":"Division of Pediatric Neurooncology German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Alten","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Medical Center Schleswig\u2010Holstein  Campus Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8396-0127","authenticated-orcid":false,"given":"Gunnar","family":"Cario","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Medical Center Schleswig\u2010Holstein  Campus Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hansj\u00f6rg","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfram","family":"Klapper","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Schleswig\u2010Holstein  Campus Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Khoury","sequence":"additional","affiliation":[{"name":"Department of Hematopathology MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Pfister","sequence":"additional","affiliation":[{"name":"Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ)  Heidelberg Germany"},{"name":"Division of Pediatric Neurooncology German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ)  Heidelberg Germany"},{"name":"Department of Pediatric Hematology and Oncology Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7477-6632","authenticated-orcid":false,"given":"Ingo","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Division of Pediatric Stem Cell Transplant and Immunology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(04)01428-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25523"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.167"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31819287b8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.0078"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21851"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1228925"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0200-x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10647"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-018-2553-9"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1511490"}],"container-title":["Pediatric Blood &amp; 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