{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:28:29Z","timestamp":1781684909705,"version":"3.54.5"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007364","name":"Fondazione CRT","doi-asserted-by":"publisher","award":["2016.1028"],"award-info":[{"award-number":["2016.1028"]}],"id":[{"id":"10.13039\/100007364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Among survivors of pediatric acute lymphoblastic leukemia (ALL), those who received hematopoietic stem cell transplantation (HSCT) conditioned with total\u2010body irradiation (TBI) show the highest risk of late complications, including cardiovascular (CV) disease. Advanced glycation end products (AGEs) have been associated with CV disease in diabetes mellitus and other clinical conditions. This study explores AGEs plasma levels, inflammatory status, and lipid profile in survivors of pediatric ALL who received HSCT conditioned with TBI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Inclusion criteria were (a) previous diagnosis of ALL at age\u00a0&lt;\u00a018 years, treated with HSCT conditioned with TBI; (b) age\u00a0&gt;\u00a018 at the time of the study enrollment; (c) off\u2010therapy for at least five years. Radiotherapy other than TBI, preexisting heart disease, glucose metabolism impairment, body mass index\u00a0&gt;\u00a025, active graft versus host disease (GvHD), smoking, or treatment with cholesterol lowering medications were exclusion criteria. Eighteen survivors and 30 age\u2010matched healthy controls were enrolled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AGEs plasma levels were markedly higher in ALL survivors than in healthy subjects (2.15 \u00b1 2.21\u00a0vs 0.29 \u00b1 0.15 pg\/mL, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Survivors also showed higher levels of high\u2010sensitivity C\u2010reactive protein (2.32 \u00b1 1.70\u00a0vs 0.88 \u00b1 1.09\u00a0mg\/dL, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), IL\u20101\u03b2 (7.04 \u00b1 1.52\u00a0vs 4.64 \u00b1 2.02 pg\/mL, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), IL17 (37.44 \u00b1 3.51\u00a0vs 25.19 \u00b1 6.34 pg\/mL, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), an increased glutathione\/reduced glutathione ratio (0.085 \u00b1 0.07\u00a0vs 0.041 \u00b1 0.036, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and slight alterations in their lipid profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data show AGEs accumulation and chronic inflammation in ALL survivors who received HSCT conditioned with TBI. These alterations may contribute to the increased risk of CV disease reported in these subjects.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28106","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T07:34:30Z","timestamp":1575963270000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Advanced glycation end products and chronic inflammation in adult survivors of childhood leukemia treated with hematopoietic stem cell transplantation"],"prefix":"10.1002","volume":"67","author":[{"given":"Francesco","family":"Felicetti","sequence":"first","affiliation":[{"name":"Transition Unit for Childhood Cancer Survivors Citt\u00e0 della Salute e della Scienza Hospital  Turin Italy"},{"name":"Department of Medical Science University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia 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