{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:58:27Z","timestamp":1787979507847,"version":"build-2784847793"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,22]],"date-time":"2019-12-22T00:00:00Z","timestamp":1576972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The International Working Group on Staging Evaluation and Response Criteria Harmonization (SEARCH) seeks to provide a universally acceptable definition of cortical bone involvement in the staging of newly diagnosed pediatric Hodgkin lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>A comprehensive literature search was performed using PubMed and Google Scholar with the search terms \u201cHodgkin lymphoma,\u201d \u201cosseous lesions,\u201d \u201cbony involvement,\u201d and \u201cpediatric.\u201d Publications reviewed included case reports, retrospective analyses, and literature reviews. Each was evaluated for study design, number of participants, median age and age range at diagnosis, percentage of pediatric patients, criteria of interest definition, diagnostic tools, study objectives, and level of evidence. The final definition was based on the available data and consensus of the SEARCH working group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five papers specifically addressing cortical bone involvement in Hodgkin lymphoma met the inclusion criteria. Eighteen papers were case reports with literature reviews; the remainder were observational cohort studies. Of these, 14 included pediatric patients (aged 0\u201021 years). The criteria for cortical bone involvement were not clearly defined in any paper, often varied within a study, and were inconsistent between publications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The SEARCH group for Childhood, Adolescent, and Young Adult Hodgkin Lymphoma (CAYAHL) proposes the following criteria as defining cortical bone involvement: any\u00a0cortical\u00a0bone biopsy\u2010proven lesion; a positive bony window lesion on computer tomography (CT), with an FDG\u2010PET positive correlate in a patient with biopsy\u2010proven Hodgkin lymphoma,\u00a0if there is no other typical skeletal pathology;\u00a0auspicious\u00a0skeletal\u00a0lesions on FDG\u2010PET or magnetic resonance imaging should be confirmed by CT or Tc\u201099m scan to distinguish cortical lesions from bone marrow involvement. Nodal masses that extend into bone with bony destruction are considered extranodal extension or \u201cE\u201d lesions and do not represent metastatic or stage IV disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28142","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T06:58:42Z","timestamp":1577084322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Definition of cortical bone involvement in the staging of newly diagnosed pediatric Hodgkin lymphoma: A report from the International Working Group on Staging Evaluation and Response Criteria Harmonization (SEARCH)"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0905-9378","authenticated-orcid":false,"given":"Jocelyn","family":"Lewis","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology Oncology Rutgers Cancer Institute of New Jersey  New Brunswick New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"McCarten","sequence":"additional","affiliation":[{"name":"Rhode Island Hospital\/Warren Alpert Medical School at Brown University  Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3396-4880","authenticated-orcid":false,"given":"Lars","family":"Kurch","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4182-9355","authenticated-orcid":false,"given":"Jamie E.","family":"Flerlage","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue C.","family":"Kaste","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee"},{"name":"Department of Diagnostic Imaging University of Tennessee Health Science Center  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regine","family":"Kluge","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietrich","family":"Stoevesandt","sequence":"additional","affiliation":[{"name":"University Clinic Halle (Saale)  Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2092-2219","authenticated-orcid":false,"given":"Stephan D.","family":"Voss","sequence":"additional","affiliation":[{"name":"Department of Radiology Boston Children's Hospital Dana\u2010Farber Cancer Institute  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara M.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Roswell Park Cancer Institute University of Buffalo Jacobs School of Medicine and Biomedical Sciences  Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Mauz\u2010K\u00f6rholz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Center for Pediatrics Justus Liebig University  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Drachtman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology Oncology Rutgers Cancer Institute of New Jersey  New Brunswick New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika L.","family":"Metzger","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,22]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1860","article-title":"Report of the committee on Hodgkin's disease staging classification","volume":"31","author":"Carbone PP","year":"1971","journal-title":"Cancer Res"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.11.1630"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.4996"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.8800"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.5229"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.05.020"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-6-34"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990301)85:5<1166::AID-CNCR22>3.0.CO;2-V"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2012.684740"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.114.3.559"},{"key":"e_1_2_9_12_1","first-page":"96","article-title":"Prognostic impact of bone involvement in Hodgkin lymphoma","volume":"55","author":"Feltl D","year":"2008","journal-title":"Neoplasma"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820115)49:2<338::AID-CNCR2820490221>3.0.CO;2-I"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-010-0019-z"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.21.1.g01ja02161"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-7-64"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008486928190"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-003-1114-3"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-012-2517-9"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-014-2715-9"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200607000-00022"},{"key":"e_1_2_9_22_1","first-page":"1407","article-title":"FDG PET can replace bone scintigraphy in primary staging of malignant lymphoma","volume":"40","author":"Moog F","year":"1999","journal-title":"J Nucl Med"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-006-0238-8"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26421"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24445"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000063682.20730.A5"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","DOI":"10.1186\/1472-6963-4-38","article-title":"Systems for grading the quality of evidence and the strength of recommendations \u2013 I: critical appraisal of existing approaches The GRADE Working Group","volume":"4","author":"Atkins D","year":"2004","journal-title":"BMC Health Serv Res"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197505)35:5<1346::AID-CNCR2820350516>3.0.CO;2-I"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-193808000-00013"},{"key":"e_1_2_9_30_1","first-page":"1059","article-title":"Primary bony involvement in Hodgkin's disease","volume":"140","author":"MacCormick R","year":"1989","journal-title":"CMAJ"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1673.1993.tb00011.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2724"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-004-0641-0"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960101)77:1<79::AID-CNCR14>3.0.CO;2-5"},{"key":"e_1_2_9_35_1","first-page":"242","article-title":"Primary multifocal osseous Hodgkin lymphoma: a case report","volume":"4","author":"Lakshmaiah KC","year":"2014","journal-title":"Int J Health Sci Res"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rlu.0000178246.19115.db"},{"key":"e_1_2_9_37_1","first-page":"218","article-title":"Osseous presentation of Hodgkin's disease: a case report and review of the literature","volume":"49","author":"Koseoglu RD","year":"2007","journal-title":"Turk J Pediatr"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2013.03.026"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.119365"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22493"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428190903189027"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.6525"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2009.0008"},{"key":"e_1_2_9_44_1","first-page":"2009","article-title":"Contribution of the 2\u2010[18F]\u2010fluoro\u20102\u2010deoxy\u2010D\u2010glucose positron emission tomography\/computed tomography to the diagnosis of primary osseous Hodgkin lymphoma","author":"Breibach F","year":"2009","journal-title":"BMJ Case Rep"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.28142","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.28142","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pbc.28142","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.28142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T03:19:45Z","timestamp":1693970385000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.28142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,22]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/pbc.28142"],"URL":"https:\/\/doi.org\/10.1002\/pbc.28142","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,22]]},"assertion":[{"value":"2018-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e28142"}}