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The study goal was to evaluate the validity and responsiveness of the PROMIS Pediatric measures in a diverse cohort of children with cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children (7\u201018 years) from nine pediatric oncology hospitals completed surveys at 72\u00a0hours preceding treatment initiation (T1) and at follow\u2010up (T2) approximately 7 to 17 days later for chemotherapy, and 4+ weeks later for radiation. Children completed PROMIS Pediatric measures (Mobility, Pain Interference, Fatigue, Depressive Symptoms, Anxiety, Psychological Stress), Memorial Symptom Assessment Scale (MSAS), and global impressions of change (GIC) questions on their symptoms and functioning at T2 reflecting on T1. Parents completed the Lansky Play\u2010Performance Status (PPS) scale and medication list for their child.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The children (<jats:italic>n<\/jats:italic>\u00a0=\u00a0482) were average age 12.9 years, 46% female, 60% Caucasian, and had diverse cancers and treatments. There were moderate to strong correlations between PROMIS Pediatric and MSAS, supporting convergent validity. In support for known\u2010groups validity, the PROMIS Pediatric average scores were statistically different (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) for most domains by PPS and if the child was on a medication (or not) for controlling a symptom. The PROMIS Pediatric measures were responsive over time in association with the GIC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a large, diverse sample of children and adolescents with cancer, there was strong evidence for the construct validity and responsiveness of the PROMIS Pediatric measures. This evidence supports PROMIS Pediatric measure use in pediatric oncology trials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28160","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T11:41:31Z","timestamp":1578310891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Expanding construct validity of established and new PROMIS Pediatric measures for children and adolescents receiving cancer treatment"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6709-8714","authenticated-orcid":false,"given":"Bryce B.","family":"Reeve","sequence":"first","affiliation":[{"name":"Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"McFatrich","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer W.","family":"Mack","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute\/Boston Children's Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6920-8526","authenticated-orcid":false,"given":"Laura C.","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Well Cornell Medicine  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shana S.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Children's National Health System  Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin N.","family":"Baker","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice S.","family":"Withycombe","sequence":"additional","affiliation":[{"name":"Clemson University School of Nursing (formerly Emory University)  Clemson South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney M.","family":"Mann","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie R.","family":"Villabroza","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6491-6649","authenticated-orcid":false,"given":"Pamela S.","family":"Hinds","sequence":"additional","affiliation":[{"name":"Children's National Health System  Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"American Cancer Society. 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