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Here, we describe three patients who received therapy with the mTOR inhibitor sirolimus with improvement in clinical symptoms, imaging, and overall well\u2010being.<\/jats:p>","DOI":"10.1002\/pbc.28162","type":"journal-article","created":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T08:52:18Z","timestamp":1578732738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Sirolimus for the treatment of juvenile nasopharyngeal angiofibroma"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0097-9293","authenticated-orcid":false,"given":"Karen S.","family":"Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Solid Tumor Program Valley Children's Hospital Cancer and Blood Disorders Center Stanford University  Madera California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"de Alarcon","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Division of Pediatric Otolaryngology \u2013 Head and Neck Surgery Center for Pediatric Voice Disorders University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2892-5369","authenticated-orcid":false,"given":"Denise M.","family":"Adams","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital Division of Hematology\/Oncology Vascular Anomalies Center (VAC), Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0820-4924","authenticated-orcid":false,"given":"Adrienne M.","family":"Hammill","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cancer and Blood Diseases Institute, Hemangioma and Vascular Malformations Center University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948409300408"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3950\/jibiinkoka.108.513"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1494"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063564"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.4.504"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812454394"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24696"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/412545"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198910000-00018"},{"key":"e_1_2_5_11_1","first-page":"75","article-title":"Long\u2010term treatment outcomes of juvenile nasopharyngeal angiofibroma treated with radiotherapy","volume":"35","author":"Mallick S","year":"2015","journal-title":"Acta Otorhinolaryngol Ital."},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi113"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2007.1012"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23124"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000298905.71259.BB"},{"key":"e_1_2_5_16_1","first-page":"196","article-title":"The risk factors for residual juvenile nasopharyngeal angiofibroma and the usual residual sites","volume":"22","author":"Liu Z","year":"2018","journal-title":"Am J Otolaryngol"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1383-z"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21667"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.12788\/j.sder.2016.053"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195401)7:1<15::AID-CNCR2820070104>3.0.CO;2-I"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-200007010-00006"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2010.07.003"},{"issue":"23","key":"e_1_2_5_23_1","first-page":"1076","article-title":"Expression of PCNA, VEGF and bFGF in endothelial cells of juvenile nasopharyngeal angiofibroma","volume":"20","author":"Sun Y","year":"2006","journal-title":"J Clin Otorhinolaryngol"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5110-5"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008207.2019.1583223"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213872"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199208000-00016"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194803000-00012"}],"container-title":["Pediatric Blood &amp; 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