{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T10:25:13Z","timestamp":1776335113142,"version":"3.51.2"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T00:00:00Z","timestamp":1578700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006313","name":"Barncancerfonden","doi-asserted-by":"publisher","award":["ST2013\u20100008"],"award-info":[{"award-number":["ST2013\u20100008"]}],"id":[{"id":"10.13039\/501100006313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006313","name":"Barncancerfonden","doi-asserted-by":"publisher","award":["TJ2014\u20100007"],"award-info":[{"award-number":["TJ2014\u20100007"]}],"id":[{"id":"10.13039\/501100006313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children and adolescents with leukemia are potentially at high risk of vitamin D inadequacy, which may have clinical relevance for skeletal morbidity, infections, and cancer outcome. This study aimed to evaluate vitamin D status at the time of diagnosis to investigate its predictors and association with overall survival in children with leukemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We included all 295 children and adolescents diagnosed with leukemia at our institution between 1990 and 2016 who had available serum sample from the time of diagnosis. We analyzed serum 25\u2010hydroxyvitamin D and parathyroid hormone levels and correlated them with clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 25\u2010hydroxyvitamin D level was deficient (&lt;\u00a025\u00a0nmol\/L), insufficient (25\u201050\u00a0nmol\/L), sufficient (50\u201075\u00a0nmol\/L), and optimal (&gt;\u00a075\u00a0nmol\/L) in 6.4%, 26.8%, 39.7%, and 27.1% of the children, respectively. Older age and a more recent time of sampling (calendar year) predicted lower 25\u2010hydroxyvitamin D level. In preschool children (age \u22646 years), lower 25\u2010hydroxyvitamin D level was also associated with acute myeloid leukemia, and a 25\u2010hydroxyvitamin D level\u00a0&lt;\u00a050\u00a0nmol\/L was associated with inferior overall survival. In school\u2010aged children (age\u00a0&gt;\u00a06 years), the 25\u2010hydroxyvitamin D level showed significant seasonal variation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It remains unclear whether vitamin D supplementation in pediatric leukemia patients will improve outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28163","type":"journal-article","created":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T08:49:42Z","timestamp":1578732582000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Vitamin D status in children with leukemia, its predictors, and association with outcome"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2817-3299","authenticated-orcid":false,"given":"Natalja","family":"Jackmann","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health University Children's Hospital  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Outi","family":"M\u00e4kitie","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institute, and Clinical Genetics Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2767-5828","authenticated-orcid":false,"given":"Arja","family":"Harila\u2010Saari","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University Children's Hospital  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University Children's Hospital  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dzeneta","family":"Nezirevic Dernroth","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Department of Clinical and Experimental Medicine Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Frisk","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health University Children's Hospital  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bonekey.2013.214"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.05.008"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0038-9"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-015-2524-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040090"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.11.038"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650111122"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.9.5968"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70349-7"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058725"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1454"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28368"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.4.1087S"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/247563a0"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/27.5.773"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508981460"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2016.03.002"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31828f3c05"},{"key":"e_1_2_11_21_1","unstructured":"Diasorin The Diagnostic Specialist.https:\/\/www.diasorin.com\/home\/. Accessed November 7 2018."},{"key":"e_1_2_11_22_1","unstructured":"Vitamin D Standardization Program (VDSP).https:\/\/ods.od.nih.gov\/Research\/vdsp.aspx. Accessed November 7 2018."},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114516004074"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22963"},{"key":"e_1_2_11_25_1","unstructured":"Livsmedelsverket[Internet].https:\/\/www.livsmedelsverket.se\/livsmedel-och-innehall\/naringsamne\/vitaminer-och-antioxidanter\/d-vitamin. Accessed October 3 2018."},{"issue":"41","key":"e_1_2_11_26_1","first-page":"2474","article-title":"[Vitamin D status in healthy children in Sweden still satisfactory. 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