{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:39:08Z","timestamp":1768315148651,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T00:00:00Z","timestamp":1578700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatitis\u2010associated aplastic anemia (AA) is a rare syndrome combining acute hepatitis of variable severity and AA. Hepatitis may be severe enough to require urgent liver transplantation (LT). Herein, we describe clinical presentation and management of a cohort of pediatric patients diagnosed with AA after undergoing LT for nonviral hepatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To describe this rare clinical situation, we performed a national survey and identified nine children treated for AA following LT during the last 10\u00a0years in France.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients were treated first for hepatic failure with urgent LT. AA was diagnosed with a median delay of 34 days [21\u2010200] from the diagnosis of hepatitis. Seven children were treated with antithymocyte globulin\/cyclosporine, one with CSA alone and one received bone marrow transplantation. At the last visit (median follow\u2010up: 4\u00a0years), outcomes were excellent: all patients were alive and in hematological remission (complete remission: 7; partial remission: 2). Immunosuppressive therapy was pursued in all patients due to the liver transplant. No unusual toxicities were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AA after LT is considered a therapeutic challenge. Nevertheless, hematological outcome is good using a standard immunosuppressive approach.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28177","type":"journal-article","created":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T08:48:15Z","timestamp":1578732495000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Management of childhood aplastic anemia following liver transplantation for nonviral hepatitis: A French survey"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2431-398X","authenticated-orcid":false,"given":"Fanny","family":"Delehaye","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology University Hospital of Caen  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalila","family":"Habes","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology AP\u2010HP Kremlin\u2010Bic\u00eatre Hospital  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Emilie","family":"Dourthe","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Immunology AP\u2010HP Robert\u2010Debr\u00e9 Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Bertrand","sequence":"additional","affiliation":[{"name":"Institute of Pediatric Hematology and Oncology Hospices Civils de Lyon University Claude Bernard Lyon 1  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard","family":"Michel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology and Research Unit EA 3279 Timone Enfants Hospital and Aix\u2010Marseille University  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00e9mie","family":"Gaudichon","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology University Hospital of Caen  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Debray","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Hepatology Reference Center for Rare Pediatric Liver Diseases Necker\u2010Enfants\u2010Malades University Hospital  Paris France"},{"name":"Department of medicine University of Paris\u2010Descartes  Sorbonne Paris\u2010Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Nelken","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology Jeanne de Flandre Hospital  CHRU Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marl\u00e8ne","family":"Pasquet","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology University hospital of Toulouse  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Blanche","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Immunology and Rheumatology AP\u2010HP Necker Enfants\u2010Malades Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Leblanc","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Immunology AP\u2010HP Robert\u2010Debr\u00e9 Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198203183061105"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198203253061204"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.18018"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04060.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198808183190702"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-8-87"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001271"},{"issue":"9","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.47102\/annals-acadmedsg.V40N9p420","article-title":"Mismatched bone marrow transplantation for severe aplastic anaemia after liver transplantation for associated acute liver failure","volume":"40","author":"Mali VP","year":"2011","journal-title":"Ann Acad Med Singap"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198704000-00034"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.4.1140.1140"},{"key":"e_1_2_9_12_1","unstructured":"European Group for Blood and Marrow Transplantation.The Complete Treatment Algorithm for SAA.https:\/\/portal.ebmt.org\/Contents\/Resources\/Library\/Slidebank\/EBMT2010SlideBank\/Documents\/EBMT%202010%20Session%20slides\/SAA_complete_treat_algorithm_v1.pdf. Accessed March 17 2019."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13853"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2016.03.015"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-3959"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00344.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4318\/tjg.2011.0222"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2017.02.003"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000431"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14691"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08194.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.917"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098142"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-0874"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103975"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12259"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24256"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.206540"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13614"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13297"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-015-0363-4"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.28177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pbc.28177","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.28177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T03:18:12Z","timestamp":1693970292000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.28177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,11]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/pbc.28177"],"URL":"https:\/\/doi.org\/10.1002\/pbc.28177","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,11]]},"assertion":[{"value":"2019-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e28177"}}