{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:56:26Z","timestamp":1788260186805,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,25]],"date-time":"2020-01-25T00:00:00Z","timestamp":1579910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite the increasing performance of allogeneic hematopoietic cell transplantation over the last decades, graft\u2010versus\u2010host disease (GVHD) remains the main cause of morbidity and mortality. The efficacy of ruxolitinib against GVHD has been demonstrated in adult studies; however, very few studies have been conducted in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>This study aimed to evaluate the efficacy of ruxolitinib in 29 children with steroid\u2010refractory acute or chronic GVHD. Twenty\u2010five (87%) patients received at least three different immune modulator agents, including methylprednisolone, before initiating ruxolitinib.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All grade 2 acute GVHD patients completely responded to ruxolitinib treatment; 82% of high\u2010grade (3\u20104) acute GVHD patients and 80% of chronic GVHD (moderate\u2010severe) patients had at least a partial response. Of seven patients with bronchiolitis obliterans, five had a partial response after ruxolitinib. Of 29\u00a0patients, 22 were administered steroids at any time in the first month of acute GVHD or the first three months of chronic GVHD during ruxolitinib usage, which was significantly tapered by the end of the observation period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Steroid\u2010refractory acute and chronic pediatric GVHD patients treated with ruxolitinib had a high overall response rate, with the additional benefit of steroid sparing.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28190","type":"journal-article","created":{"date-parts":[[2020,1,25]],"date-time":"2020-01-25T11:40:13Z","timestamp":1579952413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Ruxolitinib salvage therapy is effective for steroid\u2010refractory graft\u2010versus\u2010host disease in children: A single\u2010center experience"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3257-7798","authenticated-orcid":false,"given":"Vedat","family":"Uygun","sequence":"first","affiliation":[{"name":"\u0130stinye University School of Medicine MedicalPark Antalya Hospital Department of Pediatric Bone Marrow Transplantation Unit  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcls\u00fcn","family":"Karasu","sequence":"additional","affiliation":[{"name":"\u0130stinye University School of Medicine MedicalPark G\u00f6ztepe Hospital Department of Pediatric Bone Marrow Transplantation Unit  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayriye","family":"Dalo\u011flu","sequence":"additional","affiliation":[{"name":"MedicalPark Antalya Hospital Department of Pediatric Bone Marrow Transplantation Unit  Antalya 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