{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:46:59Z","timestamp":1787870819372,"version":"build-2784847793"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,9]],"date-time":"2020-02-09T00:00:00Z","timestamp":1581206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data on management of gray zone lymphoma (GZL) in children and adolescents are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>This retrospective study assessed clinical characteristics and outcome in six Austrian patients with GZL less than 18 years of age (male\u2010to\u2010female ratio: 1:1; median age: 15.8 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two patients each had a classical Hodgkin lymphoma (cHL)\u2010like and composite GZL subtype, and one patient each had a large B\u2010cell non\u2010Hodgkin lymphoma (LBCL)\u2010like and sequential GZL subtype. All had advanced disease with mediastinal and extranodal involvement. Five patients received an LBCL\u2010 and one patient a cHL\u2010directed polychemotherapy \u00b1 radiotherapy. Out of the former patients, three survived, including two who relapsed and underwent high\u2010dose chemotherapy with autologous stem cell rescue. The latter patient survived.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>GZL remains a diagnostic and therapeutic challenge, necessitating the development of novel treatment concepts performed in a prospective setting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28206","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T06:12:23Z","timestamp":1581315143000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Management of children and adolescents with gray zone lymphoma: A case series"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6952-1339","authenticated-orcid":false,"given":"Thomas","family":"Perwein","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics and Adolescent Medicine Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herwig","family":"Lackner","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics and Adolescent Medicine Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Ebetsberger\u2010Dachs","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Kepler University Hospital Linz  Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Beham\u2010Schmid","sequence":"additional","affiliation":[{"name":"Institute for Pathology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klara","family":"Zach","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics and Adolescent Medicine Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Tamesberger","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Kepler University Hospital Linz  Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Simonitsch\u2010Klupp","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roswitha","family":"L\u00fcftinger","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology St. Anna Children's Hospital Department of Pediatrics and Adolescent Medicine Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dworzak","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology St. Anna Children's Hospital Department of Pediatrics and Adolescent Medicine Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Mann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology St. Anna Children's Hospital Department of Pediatrics and Adolescent Medicine Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Benesch","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics and Adolescent Medicine Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9285-6898","authenticated-orcid":false,"given":"Andishe","family":"Attarbaschi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology St. Anna Children's Hospital Department of Pediatrics and Adolescent Medicine Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Austrian Society of Pediatric Hematology and Oncology and the Austrian Berlin\u2010Frankfurt\u2010M\u00fcnster (BFM) Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,9]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"342","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow 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