{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:15Z","timestamp":1786978275593,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T00:00:00Z","timestamp":1590796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010128","name":"Lasten Sy\u00f6p\u00e4s\u00e4\u00e4ti\u00f6 V\u00e4reen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006383","name":"Sy\u00f6p\u00e4j\u00e4rjest\u00f6t","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006383","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with high\u2010risk neuroblastoma (HR NBL) treated with myeloablative regimens are reported to be at risk for cardiovascular morbidity, and this risk may be increased by impaired renal function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>Long\u2010term renal function was assessed in a national cohort of 18 (age 22.4 \u00b1 4.9\u00a0years) HR NBL survivors by plasma creatinine (P\u2010Cr), urea, and cystatin C (P\u2010Cys C) concentrations, urine albumin\/creatinine ratio (ACR), and estimated glomerular filtration rate (eGFR). Ambulatory blood pressure was monitored, and common carotid intima\u2010media thickness (CIMT) and left ventricular mass index (LVMI) were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant difference in P\u2010Cr, P\u2010Cys C, or eGFR was found between the NBL survivors and the age\u2010 and sex\u2010matched 20 controls.\n                      <jats:italic>P<\/jats:italic>\n                      \u2010Cys C\u2013based eGFR (eGFRcysc) was significantly lower than the P\u2010Cr\u2013based eGFRcr (97 \u00b1 17\u00a0mL\/min\/1.73\u00a0m\n                      <jats:sup>2<\/jats:sup>\n                      vs 111 \u00b1 19\u00a0mL\/min\/1.73\u00a0m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) among the NBL survivors. The eGFRcysc was below normal in 28%, and ACR was above normal in 22% of the NBL survivors. Abnormal blood pressure was found in 56% of the survivors, and an additional 17% were normotensive at daytime but had significant nocturnal hypertension. Both ACR and P\u2010Cys C were associated with nighttime diastolic hypertension.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Long\u2010term survivors of childhood HR NBL showed signs of only mild renal dysfunction associated with diastolic hypertension. Elevated ACR and P\u2010Cys C were the most sensitive indicators of glomerular renal dysfunction and hypertension in this patient cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.28209","type":"journal-article","created":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T09:54:19Z","timestamp":1590832459000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Long\u2010term renal prognosis and risk for hypertension after myeloablative therapies in survivors of childhood high\u2010risk neuroblastoma: A nationwide study"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5464-8185","authenticated-orcid":false,"given":"Anu","family":"Suominen","sequence":"first","affiliation":[{"name":"Division of Hematology\u2010Oncology and Stem Cell Transplantation Children's Hospital University of Helsinki and Helsinki University Hospital, Helsinki  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Hospital University of Helsinki and Helsinki University Hospital, Helsinki  Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla M.","family":"Saarinen\u2010Pihkala","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology and Stem Cell Transplantation Children's Hospital University of Helsinki and Helsinki University Hospital, Helsinki  Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsi","family":"Jahnukainen","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology and Stem Cell Transplantation Children's Hospital University of Helsinki and Helsinki University Hospital, Helsinki  Finland"},{"name":"Department of Women's and Children's Health Karolinska Institute and University Hospital  Stockholm 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