{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:53:00Z","timestamp":1783666380762,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with sickle cell disease (SCD) are at increased risk for osteomyelitis (OM). Diagnosis of OM in SCD is challenging as the clinical presentation is similar to a vasoocclusive crisis (VOC) with no diagnostic gold standard. We report characteristics and outcomes of OM in SCD patients treated at our center over 10\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design\/Method<\/jats:title><jats:p>We conducted a retrospective analysis of patients with SCD who were treated for OM at our center over a 10\u2010year period (2006\u20102016). Cases were identified utilizing radiology data mining software. Radiology reports and medical charts of potential OM cases were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010eight children with SCD were treated for OM at our institution. Patients treated for OM were largely similar to patients treated for a VOC. However, patients treated for OM had significantly higher C\u2010reactive protein (10 mg\/dL vs 5.58 mg\/dL, <jats:italic>P<\/jats:italic> = 0.03) and erythrocyte sedimentation rate (60 mm\/h vs 47 mm\/h, <jats:italic>P<\/jats:italic> = 0.02). Magnetic resonance imaging (MRI) findings were consistent with OM in 18 (64%) patients and indeterminate in the remaining. Based on clinical, laboratory, and radiological findings, the diagnosis of OM was considered confirmed in 3 patients, probable in 6 patients, and presumed in 19 patients. Nontyphoidal <jats:italic>Salmonella<\/jats:italic> was isolated from cultures in 9 (32%) patients, while no organism was identified in 19 (67%) patients. All patients were treated with antibiotics. Six patients (21%) required surgical interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>OM continues to pose diagnostic challenges. Most patients are treated for OM without definitive confirmation. Nontyphoidal <jats:italic>Salmonella<\/jats:italic> was the only organism identified in our cohort.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28225","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T11:32:50Z","timestamp":1581939170000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Characteristics and outcomes of osteomyelitis in children with sickle cell disease: A 10\u2010year single\u2010center experience"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0246-782X","authenticated-orcid":false,"given":"Julie K.","family":"Weisman","sequence":"first","affiliation":[{"name":"Division of Hematology Children's National Health System  Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4277-7523","authenticated-orcid":false,"given":"Robert 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