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Eight of the 13 patients with initial hearing loss (61%) showed objective hearing improvement within six months of treatment. No patients showed hearing deterioration during therapy; however, only two patients showed objective radiological response. Seven of eight patients had tumor progression or worsening hearing loss upon cessation of treatment. Bevacizumab was well tolerated with no patients discontinuing therapy. Bevacizumab appears to postpone hearing loss in childhood NF2\u2010associated vestibular schwannomas, but responses are not durable, suggesting that either longer maintenance therapy or new strategies are required.<\/jats:p>","DOI":"10.1002\/pbc.28228","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T05:37:28Z","timestamp":1583213848000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Bevacizumab for NF2\u2010associated vestibular schwannomas of childhood and adolescence"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6364-5784","authenticated-orcid":false,"given":"Samuele","family":"Renzi","sequence":"first","affiliation":[{"name":"Division of Haematology\/Oncology Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orli","family":"Michaeli","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Division of Haematology\/Oncology Schneider Medical Center of Israel  Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Salvador","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Department Neurocutaneous Disorders and Cancer Predisposition Unit Sant Joan de Deu  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Alderete","sequence":"additional","affiliation":[{"name":"Service of Hematology\/Oncology Hospital JP Garrahan  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas Fernandez","family":"Ponce","sequence":"additional","affiliation":[{"name":"Service of Hematology\/Oncology Hospital JP Garrahan  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Zapotocky","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology Second Medical School Charles University and University Hospital Motol  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan R.","family":"Hansford","sequence":"additional","affiliation":[{"name":"Children's Cancer Centre Royal Children's Hospital  Melbourne Australia"},{"name":"Division of Cancer  Murdoch Children's Research Institute  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vajiranee S.","family":"Malalasekera","sequence":"additional","affiliation":[{"name":"Children's Cancer Centre Royal Children's Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Toledano","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology Schneider Medical Center of Israel  Petah Tikva Israel"},{"name":"Sackler Medical School Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Maguire","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6832-6539","authenticated-orcid":false,"given":"Eric","family":"Bouffet","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6557-895X","authenticated-orcid":false,"given":"Vijay","family":"Ramaswamy","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Department of Medical Biophysics and Paediatrics University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1599-7080","authenticated-orcid":false,"given":"Lorena V.","family":"Baroni","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Service of Hematology\/Oncology Hospital JP Garrahan  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"issue":"5","key":"e_1_2_7_2_1","first-page":"575","article-title":"Conference statement. 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