{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:16:28Z","timestamp":1792732588583,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Pediatric oncology patients admitted to the pediatric intensive care unit (PICU) are at high risk of mortality. This study aims to describe the epidemiology of and the risk factors for mortality in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>This is a retrospective cohort study including all consecutive PICU oncology admissions from 2011 to 2017. Demographic and clinical risk factors between survivors and nonsurvivors were compared. Both univariate and multivariate Cox proportional hazard regression models were used to quantify the association between 60\u2010day mortality and admission categories, accounting for other covariates (Pediatric Risk Of Mortality [PRISM] III score and previous bacteremia).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The primary outcome was 60\u2010day mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median (interquartile range) age and PRISM III scores of pediatric oncology patients admitted to the PICU were 7 (3, 12) years and 3 (0, 5), respectively. The most common underlying oncological diagnoses were brain tumors (73\/200 [36.5%]) and acute lymphoblastic leukemia (36\/200 [18.0%]). Emergency admissions accounted for approximately half of all admissions (108\/200 [54.0%]), including cardiovascular (24\/108 [22.2%]), neurology (24\/108 [22.2%]), respiratory (22\/108 [20.4%]), and \u201cother\u201d indications (38\/108 [35.2%]). The overall 60\u2010day mortality was 35 of 200 (17.5%). Independent risk factors for mortality were emergency respiratory and neurology categories of admission (adjusted hazard ratio[aHR]: 5.62, 95% confidence interval [95% CI]: 1.57, 20.19; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.008 and aHR: 6.96, 95% CI: 2.04, 23.75; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002, respectively) and previous bacteremia (aHR: 3.37, 95% CI: 1.57, 7.20; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Emergency respiratory and neurology admissions and previous bacteremia were independent risk factors for 60\u2010day mortality for pediatric oncological patients admitted to the PICU.\u00a0<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28242","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T20:49:33Z","timestamp":1584564573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Critical illness epidemiology and mortality risk in pediatric oncology"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4346-6188","authenticated-orcid":false,"given":"Pravin","family":"RR","sequence":"first","affiliation":[{"name":"Department of Pediatrics KK Women's &amp; Children's Hospital  Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica Ee Kar","family":"Tan","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"Department of Pediatric Subspecialties Pediatric Hematology\/Oncology Service, KK Women's &amp; Children's Hospital  Singapore"},{"name":"Duke\u2010NUS Medical School  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehena","family":"Sultana","sequence":"additional","affiliation":[{"name":"Center for Quantitative Medicine Duke\u2010NUS Medical School, The Academia  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koh Cheng","family":"Thoon","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"Duke\u2010NUS Medical School  Singapore"},{"name":"Infectious Disease Service Department of Pediatrics KK Women's &amp; Children's Hospital  Singapore"},{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Yoke","family":"Chan","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"Department of Pediatric Subspecialties Pediatric Hematology\/Oncology Service, KK Women's &amp; Children's Hospital  Singapore"},{"name":"Duke\u2010NUS Medical School  Singapore"},{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8430-4217","authenticated-orcid":false,"given":"Jan Hau","family":"Lee","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"Duke\u2010NUS Medical School  Singapore"},{"name":"Children's Intensive Care Unit, Department of Pediatric Subspecialties KK Women's &amp; Children's Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7987-4303","authenticated-orcid":false,"given":"Judith Ju\u2010Ming","family":"Wong","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"Duke\u2010NUS Medical School  Singapore"},{"name":"Children's Intensive Care Unit, Department of Pediatric Subspecialties KK Women's &amp; Children's Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2010.03.007"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200112000-00007"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21670"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.110.000141"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703384"},{"issue":"2","key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.47102\/annals-acadmedsg.V46N2p44","article-title":"Risk factors for mortality in Asian children admitted to the paediatric intensive care unit after haematopoietic stem cell transplantation","volume":"46","author":"Santhanam H","year":"2017","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181a330ef"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/2110-5820-2-14"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.07.014"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000042"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-018-0164-6"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199605000-00004"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31824e68cf"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-6553(88)90053-3"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000149131.72248.E6"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.09.020"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.3.294"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31828aebc8"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2012.08.017"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2014.05.012"}],"container-title":["Pediatric Blood &amp; 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