{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:05:57Z","timestamp":1780718757167,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T00:00:00Z","timestamp":1583107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006058","name":"St. Baldrick's Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006058","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The role of adjuvant radiotherapy (RT) remains unclear in patients with localized, completely resected (group I) alveolar rhabdomyosarcoma (ARMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>Patients with group I ARMS enrolled on any one of three prior Children's Oncology Group (COG) clinical trials (D9602, D9803, or ARST0531) were analyzed. All patients received systemic chemotherapy and 36\u00a0Gy adjuvant RT (if given) to the primary site at week 12 or week 4 for D9602\/D9803 and ARST0531, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010six patients with group I ARMS were treated on D9602 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06), D9803 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a017), or ARST0531 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a013), of whom 24 (67%) were male. The median age was 4.1 years (range, 0.8\u201045.8). Twenty (56%) patients had an unfavorable primary site, and 10 (28%) had tumors\u00a0&gt;\u00a05\u00a0cm.\n                      <jats:italic>FOXO1<\/jats:italic>\n                      \u2010fusion status was negative, positive, and unknown in 10 (28%), 15 (42%), and 11 (30%) tumors, respectively. Twenty\u2010two (61%) patients received RT. Overall, the four\u2010year event\u2010free survival (EFS) and overall survival (OS) were 70.8% and 88.3%, respectively. Patients with\n                      <jats:italic>FOXO1<\/jats:italic>\n                      positivity who received RT had superior EFS compared with those who did not (77.8%\u00a0vs 16.7%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.03). Among 10 patients who were\n                      <jats:italic>FOXO1<\/jats:italic>\n                      negative, the outcome was similar with or without\u00a0RT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Although limited by a small sample size, data from this study support the routine use of adjuvant RT in patients with\n                      <jats:italic>FOXO1<\/jats:italic>\n                      \u2010positive disease even after complete resection. Additionally, omitting adjuvant RT is rational for patients with\n                      <jats:italic>FOXO1<\/jats:italic>\n                      \u2010negative ARMS and will be prospectively investigated in the current COG trial ARST1431.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.28243","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:37:06Z","timestamp":1583195826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Do children and adolescents with completely resected alveolar rhabdomyosarcoma require adjuvant radiation? A report from the Children's Oncology Group"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8440-1263","authenticated-orcid":false,"given":"Jamie M.","family":"Aye","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Children's of Alabama University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueh\u2010Yun","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of Public Health and Health Professions College of Medicine University of Florida  Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of Public Health and Health Professions College of Medicine University of Florida  Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7591-956X","authenticated-orcid":false,"given":"Erin R.","family":"Rudzinski","sequence":"additional","affiliation":[{"name":"Department of Pathology, Seattle Children's Hospital University of Washington  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odion T.","family":"Binitie","sequence":"additional","affiliation":[{"name":"Department of Surgery Johns Hopkins All Children's Hospital  St. Petersburg Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshni","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"Department of Pediatric General and Thoracic Surgery, Cincinnati Children's Medical Center University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5234-4134","authenticated-orcid":false,"given":"Suzanne 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