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Although the timing of surgery is different in COG (upfront surgery) and SIOP (upfront chemotherapy with delayed surgery), both are effective strategies and have the same survival. Fewer patients are treated with radiotherapy in the SIOP trials but with higher doses. The prognostic significance of biological markers such as 1q gain and clinical outcomes with novel radiation techniques such as intensity modulated radiation therapy will be determined in upcoming clinical trials. A closer collaboration between COG and SIOP could help promote research and improve the clinical outcomes of children with Wilms tumor.<\/jats:p>","DOI":"10.1002\/pbc.28257","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T07:40:19Z","timestamp":1600155619000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Wilms tumor"],"prefix":"10.1002","volume":"68","author":[{"given":"Luke","family":"Pater","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Melchior","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Saarland University Hospital  Homburg 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