{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:09:16Z","timestamp":1791443356399,"version":"4.3.3"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T00:00:00Z","timestamp":1587772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1U01CA199222\u201001"],"award-info":[{"award-number":["1U01CA199222\u201001"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA054174"],"award-info":[{"award-number":["P30 CA054174"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UO1 CA199297"],"award-info":[{"award-number":["UO1 CA199297"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>VTP\u201050469 is a potent inhibitor of the menin\u2010MLL1 interaction and is implicated in signaling downstream of EWSR1\u2010FLI1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>VTP\u201050469 was evaluated against seven Ewing sarcoma (EwS) xenograft models and in vitro against EwS cell lines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>VTP\u201050469 showed limited antitumor activity, statistically significantly slowing tumor progression in four tumor models but with no evidence of tumor regression. In vitro, the IC<jats:sub>50<\/jats:sub> concentration was 10\u00a0nM for the mixed lineage leukemia (MLL)\u2010rearranged leukemia cell line MV4;11, but\u00a0&gt;\u00a03 \u03bcM for EwS cell lines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In contrast to its high level of activity against MLL1\u2010rearranged leukemia xenografts, VTP\u201050469 shows little activity against EwS models.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.28284","type":"journal-article","created":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T12:24:51Z","timestamp":1587817491000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Evaluation of VTP\u201050469, a menin\u2010MLL1 inhibitor, against Ewing sarcoma xenograft models by the pediatric preclinical testing consortium"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3212-2363","authenticated-orcid":false,"given":"Raushan T.","family":"Kurmasheva","sequence":"first","affiliation":[{"name":"UT Health San Antonio Greehey Children's Cancer Research Institute  San Antonio Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhik","family":"Bandyopadhyay","sequence":"additional","affiliation":[{"name":"UT Health San Antonio Greehey Children's Cancer Research Institute  San Antonio Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Favours","sequence":"additional","affiliation":[{"name":"UT Health San Antonio Greehey Children's Cancer Research Institute  San Antonio Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Del","family":"Pozo","sequence":"additional","affiliation":[{"name":"UT Health San Antonio Greehey Children's Cancer Research Institute  San Antonio 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